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T3 wk 2 exam study
T3 wk 2 study prep for exam
| Question | Answer |
|---|---|
| Pharmacokenetics | how the body handles the drug, how the drugs are changed, secreted, and eliminated. |
| Plasma Concentration | a measurement of the level & concentration of a specific drug AFTER the drug has been absorbed; how much of the drug is bound to the cells & how much is not. |
| Distribution | some particles bind to plasma proteins, others free float. the free floating are more bioavailable. |
| Absorption | depends on how the drug enters the body (oral:first-pass effect, anything else: absorbed through the bloodstream, also depends on the type of drug (the design, how its used (liquids absorb faster because they are already broken down) |
| Cell Membranes | once the drug hitches a ride w/plasma it then attempts to enter these semi-permable membranes (linings are made up of lipids(fat), protein |
| Smei-permable Membranes (cell membranes/bouncers) | barriers that permit the entrance of some materials and the exit of others |
| Membrane Transport Mechanisms (no energy) | Passive Diffusion (no energy, concentration from high to low), Facilitated (no energy, carrier protein helps to get into cell) |
| Membrane Transport Mechanisms (energy) | Active Transport (cost cell energy, accumulation of a drug outside a cell), Pinocytosis (energy, cell engulfs the drug) |
| Solubility | all drugs have to b lipid or water soluble in order for it to be absorbed thru the GI tract. the more lipid-soluble the drug is, the faster it is absorbed into the cell. too much lipid causes delayed absorption |
| Ionization | drugs are eith ionized these do NOT cross cell membranes) or unionized (DO cross cell membranes-have a more lipid make-up) (NaC1). ionized ( |
| Cell Walls are | electrically charged, therefor if a drug needs to enter a cell it will b unionized so that it will attach or enter into a cell. |
| Equilibrium | 2 tissues that determine the degree to which a drug is bound to a protein site: the binding affinity and the number of available sites on the cells. |
| Salt Forms | effect bioavailability (the amount of drug that is available for use) |
| Clearance | how thw drug will be cleared and how fast. drugs are eliminated from the body at the same rate at which they are absorbed. |
| Chemical Dependancy | taking a certain drug (prescribed or not) for a specific period, but NOT to the point of addiction. |
| Addiction | is both psychological (mind) and physiological (body)dependency. |
Created by:
thenry75
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