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PepticUD/GERD
pharmacology exam 4
| Question | Answer |
|---|---|
| What does PUD stand for? | peptic ulcer disease |
| What is PUD? | erosion and acute inflammation of the mucosa layer of GI tract |
| Where can PUD be? | stomach (gastric) or small intestine (duodenum) |
| What are risk factors of PUD? | family history, blood group O, smoking, beverages/foods with caffeine, drugs; steroids, aspirin, NSAIDS, excessive stress, h. pylori |
| Primary cause of PUD? | infection with H. pylori |
| What type of bacteria is H. Pylori | gram negative |
| H. pylori is associated with 80% of ____ | duodenal ulcers |
| H. pylori is associated with 70% of ___ | gastric ulcers |
| What is used to treat h. pylori | antibiotics |
| Two or more antibiotics are given for what reason? | increase effectiveness or therapy and to lower the potential for bacterial resistance |
| Antibiotics are used in combination with? | proton pump inhibitor or H2 receptor antagonist |
| Bismuth compounds are sometimes used because? | they inhibit bacterial growth and prevent h. pylori for adhering to gastric mucuosa |
| Stomach ulcer | gastric |
| Small intestine ulcer | duodenal |
| Symptoms of gastric ulcer | anorexia, weight loss, vomiting |
| Symptoms of duodenal ulcer | gnawing, burning 1-3 hours after eating, black tarry stool, bright red vomitus |
| Which ulcer is more common | duodenal |
| Which ulcer is more dangerous | gastric |
| What is the action of metoclopramide (reglan) and why is it used? | used for short term therapy of sympatomatic PUD patients who failed to respond to first-line agents |
| What does simethicone/Mylicon do? | reduces gas bubbles that cause bloating |
| What are the goals of PUD pharmacology? | relief of symptoms, promote healing of the ulcer, and prevent future recurrence |
| Gastric ulcer remission? | infrequent or absent |
| duodenal ulcer remission? | recur after months of remission |
| treatment of h. pylori with only antiulcer drugs results in | very high recurrence rate of PUD |
| Proton pump inhibitors are best for GERD, when should you take them | before breakfast on an empty stomach |
| What are some non-medication ways to help treat GERD? | elevating head of bed, avoiding fatty or acidic foods, eat smaller meals 3 hours before bed, eliminate tobacco and alcohol |
Created by:
bkgrota
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