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wcc pharmacology

WCC pharmacology

adverse reaction A result of drug therapy that is neither intended nor expected in normal therapeutic use and that causes significant, sometimes life-threatening conditions
agonist drug that binds to a cell receptor and causes action Stems from the Greek agonistes, 'contestant', from agon, 'contest'. An agonist is a chemical contestant or contender.
antagonist drug that inhibits or block the response of a cell when bound to its receptor
drug A drug is any biological substance, synthetic or non-synthetic, that is taken for non-dietary needs
efficacy Is the ability to produce a desired amount of a desired effect
extra label use drug used in manner not specifically described on the FDA-approved label
half-life the time required for the drug in the body to be reduced by half of its original level
metabolism the chemical alteration of drug molecules into metabolites by the body cells of animals; AKA biotransformation.
parenteral adminstered by routes other then the GI track
partition coefficient A partition coefficient or distribution coefficient is a measure of differential solubility of a compound in two solvents.
prescription an order, written by a licensed veterinarian, to a pharmacist to prepare the prescribed medicine.
drugs A medication is a drug taken to cure or reduce symptoms of an illness or medical condition, or may use as preventive medicine that has future benefits but does not treat any existing or pre-existing diseases or symptoms
regimen regulated system, as of diet, therapy, or exercise, intended to promote health or achieve another beneficial effect
residue broadly, is anything left behind by a reaction or other process.
withdrawal time Discontinuation of the use of an addictive substance. The physiological and mental readjustment that accompanies such discontinuation
veterinarian-client-patient relationship a relationship between a vet and a client for which the vet assumes the responsiblity for making clinical judgements regarding the health of the animals and the need for medical treatment, and the client agrees to follow advice
pharmacology study of drugs: history, source, physical and chemical properties, drugs effects and therapeutic uses
5 rights of drug admin patient, drug, dose, time, route
Routes PO, Topical, SQ, IM, IV
Barriers Blood-Brain, Blood-Intestinal, Blood-Mammary, Blood-aqueous, Blood-Placenta
Pharmacokinetics study of absorbtion, distribution, metabolism and excretion of a drug from the body and the rate.
parmacodynamics effecs of a drug ont he body and the mechanisms by which the drug acts
absorption methods passive; diffusion..active; active transport from < concentration > concentration; pinocytosis; formation of invaginations by the cell membrane which close/break to form fluid-flld valuoles
metabolism AKA biotransformation, occurs primarily in liver
excretion kidneys, lungs, bowels, mammary glands, sweat
ED 50 dose of drug that is effective in 50% of tested pop
LD 50 dose of the drug that is lethal in 50% of the tested pop
therapeutic index LD 50/ED 50; distance between the drugs effectivness level and toxicity level > the value safer
therapeutic ratio LD 25/ED 75; better then the indes
half-life time it takes for the original conc to be reduced by 50%; T 1/2
Label requirements, mftr drug name, drug strength, mftr name and addr, CS Classification, Mftr control #, Exp date, instructions
oral cross GI
Topical must be absorbed into the cells of the skin or MM to be effective
SQ absorbed from injection site
IV bloodstream, immediate blood level of drug
slowest to fastest PO<<SQ<<IM<<IV<<IC/IT
fastest to slowest IC/IT>>IV>>IM>>SQ>>PO
absorption goal to acheive adequate abs at the receptor organ
Metabolism/Biotransformation liver; detox and conjugation for excretion
conjugation biotransformed into a metabloite:In metabolism, conjugation is a biochemical process to bind a substance to an acid and thereby deactivating its biological activity, making it water-soluble, and facilitating its excretion.
excretion Kidneys primary, (test creatinine, BUN) Lungs, bowels, mammary glands, sweat
Variation factors disease state, nutritive state, hydration, temperament, history, genetics
manufacturer label name, strenght, qty, name/address, CS classification, Control #, exp date, instructions
Pharmacy label vet name, addr, phone, client, ID animal, date, mediation, directions, cautions, strength
DEA controlled substance
FDA V/C/P relationship, extra label and label requir., requir reliable analytical methods for detect of residuals in foodstuffs, withdrawal periods for food animals----approval
EPA topical pesticides
USDA develop and approve biologicals, vaccines etc.
toxicity eval dose at which a drug induces organ or tissue damage
teratogenicity capacity to cause birth defects
Therapy Tx of disease
Kinetics study of motion
para- apart from
entero intestine
intravenous within the vein
intramuscular within the muscle
subcutaneous beneath the skin into the subdermis
intraperitoneal within the abdominal body cavity
epidural/subdural/intrathecal above the dura matter of the meninges etc.
intraarterial within the arterh
intradermal within the skin
intracardiac within the heart
intradedullary/intraosseious within the medullary cavity of the bone
loading dose inital dose given to get concentation up to the theraputic range
maintenace dose dose that maintaines the therapueutic range
passive diffusion movement of atoms, ions or molecules from an area of high conc to an area of low
facilitated diffusion utilizes a special carrier molecule
active transport carrier molecule and energy
chloramphenicol blood-brain barrier (is a bacteriostatic antibiotic)
insulin blood-acqueous barrier (Insulin cannot be taken by mouth because it would be destroyed by digestion. Instead, most people who need insulin take insulin shots. )
griseofulvin blood-placenta barrier (Griseofulvin is used to treat skin infections such as jock itch, athlete's foot, and ringworm; and fungal infections of the scalp, fingernails, and toenails)
Created by: wccvettech