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RT 140 Ch.6

Radiation Protection

Law of Bergonie and Tribondeau 1. Stem cells are radiosensitive. 2. Younger tissues and organs are more radiosensitive 3. High Metabolic activity - radiosensitivity is high. 4. Increase proliferation rate for cells and the growth rate for tissues, the radiosensitivity also increas
Radiation Dose Response Relationship Described as a mathematical relationship between different radiation doses and the magnitude of the observed response.
what are 2 important applications in radiology for the Radiation Dose Response Relationship? 1. Experimentally determined relationships can be used to design therapeutic treatment routines 2. Radiobiologic studies have been designed to provide information on the effects of low-dose irradiation.
The studies and the dose-response relationships obtained are the basis for? Radiation control
Every radiation dose-response has what two characteristics? 1. It is either linear or nonlinear 2. It is either threshold or non-threshold
Which model is more conservative, and is used to establish dose limits for occupational exposure? Linear Non Threshold
Which model implies that a biologic response to ionizing radiation is proportional to Dose? Linear Non Threshold
Which model estimates the risk associated with low level radiation (BEIR)? Linear Quadratic Model
Which is a more accurate model at reflecting somatic and genetic effects at Low Dose levels from Low LET radiation? Linear Quadratic Model
Threshold (Non-Stochastic) effects Point in which a respsonse or reaction to increasing stimulation first occurs
Non threshold (Stochastic) effects Any radiation dose will produce an effect * “No radiation Dose is believed to be safe”
Which effect is an ALL or NONE phenomenon. Non threshold (Stochastic) effects
What has a deterministic effect? Non-Stochastic (Threshold)
What stage is characterized by nausea, vomiting, and diarrhea (N-V-D)? Prodromal stage
What occurs within minutes to hours of exposure and continues for up to one or two days? Prodromal stage
What dose must be greater than 100 cGy before the onset of syndrome? Prodromal stage
What subject is free of visible effects there is a sense of well being? Latent stage
What duration is dose related 100 to 500 cGy (weeks), greater than 5000 cGy (hours)? Latent stage
What stage is either recovery or death from the radiation injures? Manifest illness stage
When does Bone Marrow Syndrome occur? Between 1 and 10 Gy * Death occurring at 2 Gy
LD 50/60 occurs at what dose? 3 to 4 Gy
When does GI syndrome occur? Between 10 and 100 Gy * Symptoms occur after 6 Gy
What is the LD for GI Syndrom? 6 to 10Gy
When does CNS syndrome occur? Greater than 50 Gy * Some occurring after 20Gy
Created by: kayg