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Ovaries
Son 140
| Question | Answer |
|---|---|
| The ovarys are the only abdominal organ not covered by? | Peritoneum |
| During fetal life they are located in the? | Lumbar region near the Kidney |
| What is the ovary location? | Posterior to uterus at level of cornu.Lie medial to external iliac vessels. Anterior to the internal vessels.Mesovarioan location |
| Regions of the ovaries | Cortex and central medulla |
| Outer region or Cortex of the ovary consists of? | Primarily of follicles in various stages of development. |
| Cortex is covered by? | A layer of dense connective tissue, the tunica albuginea ( cover the cell) and a thin layer of cells, the germinal epithelium |
| Central medulla is composed of? | Connective tissue containing blood, nerves, lymphatic vessels and some smooth muscle at the region of the hilum |
| Vascular supply ( dual blood supply) | Arterial and Venous |
| Arterial blood supply | 1. Ovarian artery,which is a branch off the abdominal aorta immediately below the renal arteries. 2. Adnexal branch of uterine artery |
| Venous blood supply | Plexus which lies posterior to the uterus, ovarian veins arise from the venous plexus. Rt vein drains to IVC Lt vein drains to LRV |
| Premenarche Ovary (before menstral cycle) | Mean: 3cm3 Volume Range: 0.2-9.1cm3 |
| Menstruating Ovary | Mean: 9.8cm3 3x2x2cm Volume Range: 2.5-21.9cm3 |
| Postmenopausal Ovary | Mean Volume: 5.8cm3 2x1.5x0.5cm Volume Range: 1.2-14.1cm3 |
| They atrophy due to estrogen decrease | Postmenopausal ovary |
| Ovarian Volume Formula | V=HxWxL/2 or Vcm3=LxWxAP diameter x 0.53 |
| Doppler of ovarian vessels | Resting state:high impedance waveform Benign mass high resistance doppler flow Malignant mass low imedance w/resistive index less than .4 & pulsatility index 1.0 |
| Doppler Formula Resistive | RI=systolic-diastolic/systolic |
| Doppler formula Pulsatility | PI=Systolic-Diastolic/Mean velocity |
| Benign has a | high resistance waveform |
| Malignant has a | low impedance waveform |
| Measurable blood flow to the ovaries varies depending upon? | menstrual cycle |
| PT w/normal menstrual cycles are best scanned in the first? | 10 days of cycle |
| 1st 7days of menstrual flow Best time for measurments,index is? | Highest |
| Signs that are worrisome for malignancy? | Intratumral vessels Low resistance flow Absence of normal diastolic notch in the doppler waveform |
| Color doppler is used to localize flow for | Pulse doppler |
| Pulsed doppler can be used to investigate the | Adnexal branch of uterine artery, ovarian artery, or intratumoral flow |
| Color doppler, some studies suggest Peripheral vascularization appear to be more common in ? | Benign tumors whereas malignant tumors tend to have more centrally located vessles. |
| Peripheral is found around the | Tumor |
| Central Distribution shows | blood flow in the center of tumor |
| Color doppler central distribution of small arteries within an ovarian mass amy be an important factor in | Malignancy |
| Detection of ovarian cancer | 1.Annual rectovaginal pelvic exam 2.CA 125 serum test 3. transvaginal ultrasound |
| Tumor Marker present in | 80% of epithlial cancers |
| Simple cyst criteria for Benign cystic ovarian masses? | Smooth, well-defined borders, no internal echos & posterior enhancment. Measure <5cm & regress |
| Result from hormonal function of ovary, common ovarian enlargment in young women & Hormonal therapy used | Functional Ovarian Cyst |
| Functional Cyst are: | Follicular, Corpus luteum, Corpus luteum of pregnancy & Theca lutein cyst. |
| Result form nonrupture of dominant follicle/failure of atersia. Simple cyst,unilateral,go away on there own | Follicular cyst |
| Result form graafian follicle w/in hr of ovulation. 1-10cm hypo w/irregular thick borders around central anechoic area internal echo Results from intracystic hemorrhage Asymptomatic, unless ruptures | Corpus Luteum cyst |
| Persist after fertilization, 3cm or more. Resolve 16 wks. Doppler reveals prominent diastolic flow Peripheral rim " ring of fire" secreates progestron | Corpus Luteum of pregnancy |
| Largest Functional cyst,result from over stimulation & high level HGC in blood. Regress after HGC removed multilocular,thin walled, bilateral 3-20cm | Theua Lutein cyst |
| Molar pregnancy can cause a | Theca cyst |
| Internal hemorrhage in follicular or corpus cyst. Endovaginal best image acute, hyperechoic & may mimic solid mass. W/time can look complex, clotted blood is echogenic & fluid level | Hemorrhagic Cyst |
| Other Benign ovarian cysts | Epithelial inclusion, Paraovarian, Peritoneal inclusion,Endometrioma |
| Arises from superfical cortex Small up to 10cm, Mostly in postmenopausal women | Epithelial Inclusion cyst |
| Arise broad ligament, 10% adnexal masses Multiple, round or ovoid(NOT surrounded by ovarian tissue) Any age common in 30-40s can't locate point of orgin | Paraovarian |
| Normal ovarian fluid trapped by peritoneal adhesion/scare tissue. Mostly premenopausal,up to 20cm Large ovoid/irregular anechoic cyst pt w/history of PID,trauma,endmetrioses | Peritoneal Inclusion cyst |
| Focal areas of endmetriosis, under 15cm. Cyst walls thick & fibrotic Multiple lesions w/echgenic, fluid filled content, solid, complex, cystic | Endometriosis |
| Endometriosis means | Overgrowth, outside uterus |
| Polycystic ovarian, Ovarian Hyperstimulation, Ovarian Remnant are all | Syndromes |
| Chronic endoocrine disorder associated w/obesity, amenorrhea, anovulation, hirsutism & infertility. Bilateral enlargement of ovary multiple "Cortical Cyst" means (Ring of Pearls) 2-6cm(or 2-5xlarger) can still have kids w/help | Polycystic ovarian syndrome "PCO" |
| Known as STEIN LEVENHAL Syndrome; infrequent periods can't ovulate, low levels of FSH so follice is not being stimulated | PCO Polycystic ovarian syndrome |
| Occurs w/women undergoing ovulation induction. Occurs after FSH is given followed by hGc women w/increased risk: young thin and some w/ploycystic ovaries; will regress w/in 6wks | Ovarian Hyperstimulation Syndrome (OHS) |
| Trying to get ovary to ovulate due to it not working. FSH stimulates follice. Done to harvest the egg for invetro | Ovulation Induction |
| Shows cystic ovarian enlarement(>5cm)& small to moderate amount of pelvic fluid abdominal distenstion, nausea, vomiting | Mild to moderate OHS |
| Shows systic ovarian enlargment w/abdominal distention, pain w/or w/out nausea,vomiting or diarrhea Ascites or pleural effusion can occur | Severe OHS |
| Complication of oophorectomy. Pt w/anatomy distorted by adhesions or endometrosis. Ovary removal is difficult w/distortion & postoperative remnants of tissue become functional & you get a cystic or complex mass | Ovarian Remnants Syndrome |
| Removal of the ovary | Oophorectomy |
| 80% of all ovarian tumors are | Benign |
| Benign ovarian tumors are categorized as? | Germ Cell Tumor Epithelial Tumor Stromal Tumor |
| In adults 95% are benign & consist of mature cycstic teratomas. 2nd largest group of masses. Account for 20% of neoplasms & occur in 1st-6th decades mostly women younger than 2yr | Germ Cell Tumor |
| Mature cystic teratomas "Dermoid cysts" of the ovary ar the most common GERM cell tumor & ovarian neoplasm.Occurs in reproductive yrs. Composed of 3 germ cell layers | Benign Cystic Teratoma |
| What ae the 3 germ layers | Ectoderm, Mesoderm, & Endoderm |
| Pure form is always benign, 15% bilateral, varies form .5-40cm. Composed of fat,hair,teeth "Dermoid" | Benign Cystic Teratoma |
| Sonographically appear w/ bright echos, hyperechoic lines & dots, shadowing, fluid-filled level,cystic, colid or complex | Apperance of a Dermoid |
| 60% measure 5-10 cm You can see the ecogenic portion (top) but not the botton Associated w/teratoma surgical removal in young pt, keep ovary | "Tip of the Iceburg" |
| Benign ovarian Teratoma contaning Throid tissue. treatment is removal. 5% pt w/this develop hyperthyroidism | Struma Ovari |
| On basis of cell type & nature of secretion most common of epithelial tumors are classified as? | Serous, Mucinous,or endmetroid |
| Most epithelial are | Adonoma or adenocarcinoma |
| Benign Epithelial Ovarian Tumors: Arise from ovarian epithelium | Serous cystadenoma,Mucinous cystdenoma, Transitional cell tumor |
| 25% of all benign ovarian tumors 50-70% of all ovarian serous tumors unilocular maybe bilateral Contains thin clear serouses fluid peak incidence 4th & 5th decades | Serous Cystadenoma |
| 20-25% of all benign ovarian tumors 75-85% of all ovarian mucinous tumors Multiloculated cystic tumor, onesided up to 50cm Peak 3rd to 5th decades | Mucinous Cystadenoma |
| More papillary projections,less common, secreates mucinous yellowish Gelly like material. contained w/in tumor | Mucinous |
| Derived form "surface epithelium" 1-2 % of all Primary ovarian tumors, less than 10cm most are 2cm 4th to 8th decades 40-80yr 96 % are primarily unilateral, hypoechic, solid,calcification may be seen | Brenners Tumor "Transitional cell tumor" |
| Benign Stromal Ovarian Tumors: account for approximately 8% of all ovarian tumors | Fibroma, Thecoma, Sertoli-Leydig tumor |
| Ovarian tumor accounts for 4% Seen in middle age size: very small to large Fibroid like tumor, attenuates sound (shadows) Associated w/Meig's Syndrome | Fibroma |
| Condition in which solid benign ovarian tumor is associated w/ascites & pleural effusions | Meig's Syndrome |
| 1% of ovarian tumors 84% in postmenopausal women, can occur in young girls, 5-10 cm can be 30cm unilateralsimilar to fibroma in appearance, shadowing, can become invasive, irrgular period in young girls ESTROGEN PRODUCING TUMOR | Thecoma |
| <0.5% of ovarian tumors all ages common in 25yr olds ANDROGEN PRODUCING UNILATERAL, 5-15cm 20% are malignant Masqulizing tumor: deep voice facial hair. Irrigular period, infertility is a sign of smaller tumors. if taken out will reoccur | Sertoli-Leydig Cell tumor |
| Estrogen tumor, small= benign;large=malignant, 95% in postmenopausal women, 5% pt associated w/endometrial carcinoma average 12cm, 50-55yr old Adenoma slow growing | Granulosa Cell Tumor |
| Ovarian cancer accounts for 4% in women. 4th leading cause of death in women Increased risk w/family history of ovarian or breast cancer high risk if ovulation lasts longer than 40yrs ( early period) | "Malignant Ovarian Tumors" |
| Malignant tumor catergories | Germ Cell, Epithelial, & Metastatic |
| 60% ovarian neoplasms are Germ Cell origin, & 1/3 are malignat | Germ Cell Tumor |
| 1st Germ Cell Tumor, most common malignant childhood & early adult life. 2nd most common observed in pregnancy. 3-5% malignancies, at any age 20-30yrs bilateral in 10-17%. Solid, round or lobulated, varies in cm up to 50cm Histologically same as Seminoma | Dysgerminoma |
| Uncommon malignant tumor 1% of all teratomas of ovary, 1st 2decades of young life, usually large up two 28cm, mostly solid but can have cystic areas Composed of all 3 embyonic layers | Immature Teratoma |
| 2nd most common malignant Germ Cell after Dysgerminoma 20-30 yrs old unilateral 3-30cm, solid w/cystic areas spread fast PT's blood will have serum increased level of ALPHAFETOPROTEIN Comes from embyonic components, can occur in testical 85% cure rat | Yolk Sac Tumor |
| end of Germ cell tumor | |
| Malignant epithelial tumor accounts for 90-95% of ovarianmalignancies | Epithelial Ovarian Tumor |
| Most common primary carcinoma of ovary 40-50%. 45-65 yrs old, bilateral 50% of time. Multilocular,Multiple Papillary projections( can go thru tumor & spread) "SEEDING" & Septations, can have echogenic foci (bright). 1/2 are greater than 15 cm | Serous Cystadenocarcinoma |
| 80% are malignant 20-25% of ovarian carcinomas associated w/ endomertum Bilateral in 28% of cases 50-60yrs old 12-20 cm cystic mass w/papillary projections | Endometroid Carcinoma |
| 5-10 % malignant ovarian tumor 4th to 7th decades, 15-20% bilateral 15-30 cm, appear cystic, multiloculated, papillary projections w/echogenci material fewer papillary projection than serouses | Mucinous Cystadenocarcinoma |
| 50-70 yrs olds, bilateral in 15-20% of cases & up to 30cm. present as complex, predominantly cystic masses associated w/Endometriosis in 50-70 %of cases, 25% come from linningof endometriotic cyst | Clear Cell Tumor |
| Mostly Benign, Maliganant Brenner's tumor larger than benign form. 10-30cm Cystic spaces & areas of hemorrhage & necrosis | Transitional Cell ( BERNNER'S) Tumor |
| Rare, caused by metastasis of mucin producing tumor. Epithelial cells implant on peritoneum & secretes a GELATINOUS material that is not absorbed well. Resembles ascites or multiple clusters of anechoic spaces abdomin can fill up w/ mucin gelly"GELLY B | PSUEDOMYXOMA PERITONEI |
| Primary cancer spread thru different routes, extension involves pelivc organ w/tumor. Peritoneal seeding, tumor cells shed from lesionthru lymphatic system & blood stream. Blocks the lymphatic system causes ascites. Estrogen receptor | Ovarian Metastatic Dieases |
| Bilateral,complex cysts reflecting presence of fluid & mucin within them, solid. common primary cancer that spread to ovary:breast,gastric & intertinal | Ovarian Metastatic Dieases |
| A Ovarian Metastatic Dieases is | Ovarian Lymphoma |
| Ovarian Lymphoma is a | Rare tumor, from the disease lymphoma elsewhere in the body. Burkitt's lymphoma affect the ovary frequently & looks like a solid hypoechoic mass |
| secondary tumor of ovary from GI TRACK, primary cancer ( usually stomach); bilateral Ascites maybe & complex looking | KRUKENBERG TUMOR |
| Treatment of Ovarian cancer | Surgery, Radiation therapy, & chemo. Early detection |
| Talcum powder has been implicated a possible factor for ovarian cancer due to? | Powder travel via genital tract & acts as an irritant promoting cancer growth |
| Has been proven not to be successful or cost effective screening tool. | Ultrasound |