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Cellular mechanisms

Cellular & Molecular drug targets for 3rd year pharmacology course

QuestionAnswer
List mechanism titles cAMP cGMP PI3K/Akt & mTOR/victor MAPK JAK/STAT & TGFR/Smad NF-kB Hedgehog, Wnt & Notch GPCRs Protein-tyrosine kinases serine/threonine kinases(Akt) Rhodopsin Ryanodine receptors (RYR) Arrestin & GRKs
Enzyme for ATP to cAMP Adenylate cyclase
Enzyme for cAMP to ATP cAMP phosphodiesterase
cAMP does what? kinase activation, including PKA activation for heterologous receptor desensitization of non-ligand bound Rs
cGMP does what? cGMP dependent protein kinases and direct ion channel activation
Enzyme for GTP to cGMP Guanylyl cyclase
Enzyme for PIP2 to IP3 + DAG Phospholipase C (PLC)
DAG activates what? PKC (receptor desensitizer)
PKA does what? Heterologous desensitization of non-ligand bound receptors
PKC does what? Heterologous desensitization of non-ligand bound receptors
IP3 does what? #Calcium mobolisation via ligand on ER
Enzyme for PIP2 to PIP3? PI3K
PI3K does what? PIP2 to PIP3
PIP3 does what? Binds both Akt & PDK-1 to membrane, makes Akt & PDK-1 more likely to interact. PDK-1 & mTOR/victor both phosphorylate Akt. Activated Akt then can cause cell death via mechanisms.
Akt does what? PIP3 binds both Akt & PDK-1 to membrane, makes Akt & PDK-1 more likely to interact. PDK-1 & mTOR/victor both phosphorylate Akt. Activated Akt then can cause cell death via mechanisms.
PDK-1 does what? PIP3 binds both Akt & PDK-1 to membrane, makes Akt & PDK-1 more likely to interact. PDK-1 & mTOR/victor both phosphorylate Akt. Activated Akt then can cause cell death via mechanisms.
Created by: seeriktus
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