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N115: Antibiotics

UCLA N115 Pharmacology Antibiotics

QuestionAnswer
Classification of Pathogens (4) Gram +/- , Cocci/Bacilli/Spirochetes, Aerobe/Anaerobe, Intracellular/Extracellular
Classification of Antimicrobial Agents (5) COMBS: Chemical Structure, Other (route, AEs, cost), Mechanism of Action, Bacteriocidal/Bacteriostatic, Spectrum of Activity
Cell Wall Synthesis Inhibitors Beta-G: Beta-lactams (cidal), Glycopeptides (cidal)
Protein Synthesis Inhibitors MALT: Macrolides (static), Aminoglycosides (cidal), Lincosamides (static), Tetracyclines (static)
DNA Gyrase/Topoisomerase Inhibitors Q: Quinolones (cidal)
Folic Acid Synthesis Inhibitors ST: Sulfonamides (static), Trimethoprim (static)
Mechanisms of Bacterial Resistance AEAA: Antimicrobial inactivation, Efflux, Alteration of Target/Receptor, Antagonize Antimicrobial
What antimicrobial is associated with superinfections? 3rd generation cephalosporins, clindamycin, or any other broad-spectrum antimicrobial
What is the classic superinfection? Pseudomembranous colitis, an infection by Clostridium Difficile, caused by Clindamycin, treated with Vancomycin or Metronidazole
What are the three types of penicillin Gs? Which has the fastest absorption? PBP: Potassium, Benzathine, Procaine. Potassium.
Clinical use of penicillin G: Most Gram + (Streptococcus and non B-lactamase-producing Staphylococcus), Gram - cocci (Neisseria gonorrhoaea), Gram - spirochetes (Treponema pallidum), Anaerobes.
What is different about penicillin V? It is stable in stomach acid and can thus be administered PO.
Created by: Wilbeezy904
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