Save
Busy. Please wait.
Log in with Clever
or

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever
or

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Antiprsitics

QuestionAnswer
TMP-SMZ (Bactrim) Uses PCP prophylaxis/treatment in HIV/ALL
TMP-SMZ Mechanism inhibits tetrahydrofolate production (Sulfamethoxazole inhibits incorporation of PABA into folic acid; Trimethoprim inhibits dihydrofolate reductase)
TMP-SMZ SE's CYP450 inhibitor Rare: agranulocytosis, aplastic anemia, Stevens-Johnson/rash SE's in 65% of AIDS pts
Pentamidine isethionate Uses PCP pneumonia Trypanosoma brucei gambiense hemolymphatic stage (IV, IM) PCP prophylaxis (inhaled)
Pentamidine isethionate Mechanism interferes with nuclear metabolism: inhibits DNA/RNA/protein synthesis
Pentamidine isethionate SE's hypotension, hypoglycemia followed by insulin dependent DM b/c destruction of pancreatic B cells AIDS pts: rare fatal pancreatitis inhaled version is well tolerated
Albendazole uses Nematodes and Invasive cestodes DOC for inoperable echinococcal liver cysts; neurocysticercosis
Albendazole mechanism binds tubulin > disrupts MT formation impairs glucose uptake in worms Can administer as single dose for worms!
Albendazole SE's corticosteroids increase its levels
Pyrantel pamoate Uses Nematodes (enterobius, ascaris, hookworm) NOT effective for whipworm (Trichiuris)
Pyrantel pamoate Mechanism causes depolarizing NM blockade & spastic paralysis in roundworm. Inhibits cholinesterases
Pyrantedl pamoate SE's GI distress
Ivermectin Uses DOC: Strongyloides, cutaneous larva migrans, onchocerciasis (w/ limited inflammation) Not effective against cestodes/trematodes b/c they have no GABA control of muscle
Ivermectin Mechanism induces GABA release > suppresses neuronal transmission > paralysis + death of parasite
Ivermectin SE's well tolerated, no CNS penetration to mess w/ our GABA
Diethylcarbamazine Uses filariasis (elephantitis) Loa Loa DO NOT use in onchocerciasis (SE's)
Diethylcarbamazine Mechanism immobilizes parasite thru hyperpolarizaiton of muscle
Diethylcarbamazine SE's Leukocytosis (resolves) Mazzotti rxn in pts with onchocerciasis (pruritis, fever, hypotension, facial edema, eosinophilia); keratinitis, uveitis, atrophy of retinal epit) Cerebral edema if level of Loa Loa infection too high
Praziquantel Uses Trematodes (Flukes) Non-invasive cestodes (Tapeworms)
Praziquantel Mechanism Unknown - Ca dependent Cx spastic paralysis in worm and vacuolization of parasite tegument
Permethrin Uses Topical - lice, fleas, mites Mosquito, sandfly repellant
Permethrin Mechanism Na channel disruption > paralysis
Permethrin SE's erythema, numbness, tingling, rash
Lindane Uses Scabies (topical)
Diethyltoluamine (DEET)Uses insect repellent (malaria, sandfly)
DEET SE's Rare toxic encephalopathy with high doses in small children
Lindane SE's Rare CNS toxicity (seizure) if applied to cracked skin
Created by: Kmoldov1
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards