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B blockers

QuestionAnswer
MOA blocks sympathetic activity, blocks binding of NE/E
B receptor types B1: heart, B2: lungs
MOA of E/adrenaline bind to B-recept coupled to Gprotein. activates adenylyl cyclase, form cAMP from ATP, cAMP activates protein kinaseA, PKA phosphorylates L-type Ca channels, Ca in, more binding to troponinC, PKA phosphylation of MLC, contraction
B blocker effect on heart - inotropy, + lusitropy, -chronotropy, -dromotropy
effect on smooth muscles (B2 more on bronchiolar and vascular than B1) sympathetic NT cause relaxation by coupling to inhib G protein, B-blocker little effect on vasculature, a recept constrict dominates. B-blocker vasoconstrict: INITIAL decrease CO (-chronotropy/inotropy)
ISA can partially activate B receptors
Bblock + ISA Inx prevent excessive bradycardia/-inotropy
Bblocker Inx ischemic heart disease (IHD):de. HR, contract, MAP, work, O2 demand. HT, HF, arrhythmias
Created by: cnlin
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