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pharm antimicrobials
| Question | Answer |
|---|---|
| endogenous infection | body's own flora |
| exogenous | external source |
| antifungals that require acidic enviro | ketoconazole, itraconazole, |
| no acidic enviro | fluconazole, voriconazole |
| nystatin | yeast infections and oral thrush |
| NRTIs | Abacavir (hypersensitivity can be fatal), didanosine (pancreatitis), lamivudine (also Hep B) |
| NNRTIs | efavirenz (no preg)delavirdine (inhibits CYP3A4) etravirine (good invetro and resistant strains) nevirapine (good preg) |
| protease inhibitors | no intracellular activation required (all navirs) |
| fosamprenavir and darunavir and tiprranavir | sulfa allergy beware |
| safest for pregnancy | lopinavir or saquinavir |
| no dosage adjust for renal in | maraviroc |
| NRTIs | emtrictabine (no kids, preg or hep issues) stavudine (atrophy of fatty areas)tenofovir (renal failure and osteo) zalcitabine (w/o food)zidovudine(used in pregnancy-14 and 34 we |