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amino and antimic
Question | Answer |
---|---|
aminoglycosides | gentamicin (most resistance), tobramycin, amikacin (most potent), streptomycin (rarely used), neomycin (oral) |
MOA | inhibit protein synthesis, no anaerobes because needs o2 to work |
SOA | aerobic bacteria only, gram pos and gram neg |
synergistic with | b-lactam antibiotics |
antimycobacterials | use for tuberculosis, never just one drug, |
1st line | isoniazid (static and cidal, CYP450 inhibitor), rifampin (gram neg, pos, and biofilm, inhibits RNA synthesis, orange red body secretions, CYP450 inducer, liver), pyranzinamide (renal adjust, cidal, hyperuricemia), ethambutol (renal, static, gout, streptom |
2nd line | ethionamide, cycloserine, amikacin, aminosalicylic acid, capreomycin, clofazimine, levofloxacin, ciprofloxacin, rifabutin, rifapentine |