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pharm antibiotic res

all the rest

QuestionAnswer
carbapenems related to b-lactams structure
spectrum of activity gram pos good (staph and strep--No MRSA), excellent gram neg (not eertapenem psuedomonas), and excellent anaerobes
pharmacokinetics IV only, penetrate CNS, renally excreted
SE similar to penicillins, siezures,more likely with imipenem
Monobactam aztreonam, monocyclic b-lactam ring, can be used with penicillin allergic patients
spectum of activity gram neg only--including pseudomonas
cell wall active agentss vancomycin, telavancin, daptomycin (rapidly bacteriocidal)
vanco drug of choice for MRSA, gram pos only, c-diff, SE red man syndrome, ototoxicity, nephrotoxicity, neutropenia
telavancin lipoglycopeptide, same as vanco MOA, gram pos only with MRSA/MRSE/Enterococcus--similar SE to vanco with higher renal problems
daptomycin most rapid, most potent, iv only, do not use for pulmonary infections--binds to surfactant--SE myopathy/myalgias, elevated CPK
Created by: larschen
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