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pharm cephalosporins

QuestionAnswer
cephalosporins are similar in structure to penicillins, more resistant than penicillins to b-lactamase
1st generation cefazolin (kefzol)cephalexin (Keflex) cephalothin (keflin) cephapirin (Cefadyl) cepharadine (Velosef)cefasroxil (duricef)
1st gen uses gram pos-No MRSA-limited gram neg
2nd gen cefaclor (ceclor), cefuroxime (ceftin) cefamandole (mandol) cefonicid (monocid) cefprozil (cefzil, loracarbef (lorabid)
2nd gen uses slightly less gram pos than 1st, more gram neg than 1st--has H. influenza, M. catarrhalis, and Neisseria
cephamycins cefotetan, cefoxitin
ceph uses not great gram pos, limited gram neg, Anaerobes!
3rd gen cephtriaxone, ceftazidime and cefoperazone(pseudomonos)
3rd gen uses broad gram neg
4th gen severely ill pt, cefepime (maxipime)
4th gen uses good staph and strep, great gram neg--IV only
5th gen MRSA!!! ceftobiprole (teflam)
pharmacokinetics can be taken with food, distro similar to penicillin, CNS penetration--1st none-2nd onlycefuroxime, 3rd all except cefoperazone
biliary excretion cefriaxone, cefoperazone
Created by: larschen
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