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pharm b-lactams

pharm antibiotic

QuestionAnswer
b-lactam penicillins
penicillins natural, antistaphylococcal, extended spectrum
b-lactams affect in cell wall synthesis affect PBP to not allow crosslinking for formation of cell wall
b-lactam MOA inhibit cell wall synthesis, only work if actively multiplying bacteria, bind to PBP's and prevent development of normal peptidoglycan structure
b-lactams only effective against actively growing bacteria that synthesize a peptidoglycan cell wall
b-lactamaze most common reason for bacterial resistance to b-lactam
b-lactamaze inhibitors cluvulanic acid, sulbactam, and tazobactam--inhibit b-lactamase--improved coverage against staph, b-lactamase producing gram neg bacilli, anaerobes
natural penicillins penicillin G, penicillin VK, benzathine penicillin
natural penicillin use gram pos, limited staph, very limited gram neg, drug of choice for syphillis
antistaph penicillins Biliary excretion!! nafcillin, oxacillin, dicloxacillin---gram pos only, NOT MRSA, but staph and strep
amino penicillins amoxicillin (can be taken with food), ampicillin, amoxicillin+clavulanic acid=augmentin (Staph), ampicillin+sulbactam=unasyn
amino use gram positive--no staph with Amox or Ampi, improved gram neg (increase with b-lactamase inhibitor) and anearobes with inhibitor
carboxypenicillins carbenicillin, ticarcillin+clavualanic acid=timentin
carboxy use gram pos, staph with inhibitor,improved gram neg, anaerobes with inhibitor
ureidopenicilllins piperacillin+tazobactam=zosyn
ureido use gram pos, staph with inihibitor, pseudomonas coverage, anaerobes with inhibitor
Created by: larschen
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