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Antineoplasti

UVa med pharm block 4

QuestionAnswer
What drug(s) is/are used to treat CML (Drug of choice)? Imantinib
What drug(s) is/are used to treat Solid Tumors? Etoposide
What is the major side effect of the Alkylating agent Mechlorethamine? Hyperuricemia
What drug(s) is/are used to treat Lung Cancer? Ifosfamide Paclitaxel
What class of drug is Mechlorethamine? Alkylating Agent
What is the mechanism of Doxorubicin? Intercalates non-specifically into DNA. Inhibits topo II
What drug(s) is/are used to treat ALL? Methotrxate 6-Mercapto Cytarabine Vincristine Prednisone L-Asparaginase (Childhood)
What drug(s) is/are used to treat Burkitt's? Methotrexate
What class of drug is Dacarbazine? Alkylating Agent
What class of drug is Cisplatin? Platinum based Alkylating Agent
What class of drug is Carboplatin Platinum based Alkylating agent
What class of drug is Thiotepa? Alkylating agent
What is the mechanism of Viblastine? Just binds tubulin and prevents mitotic spindle (no other actions, unlike Vincristine)
What class of drug is Ifosfamide? Alkylating agent
What class of drug is Carmustine? Alkylating agent
What is the mechanism of Danorubicin? Intercalates DNA and inhibits topo II
Which antineoplastic can cause severe hypertension, and GI tract perforation? Bavacizumab (it can also cause heart failure)
What class of drug is Methotrexate? Anti-metabolite (Inhibits DHFR)
Which antineoplastic METHYLATES DNA? Dacarbazine
What is the mechanism of Bavacizumab? Anti-VEGF Monoclonal Ab. Inhibits angiogenesis of tumors.
What drug(s) is/are used to treat GI Stromal Tumors? Imantinib
What drug(s) is/are used to treat Adenocarcinomas? 5-Fluorouracil
What class of drug is Cyclophosphamide Aklylating Agent
What class of drug is 5-Fluorouracil? Anti-metabolite (Nucleotide analog. Inhibits Thymidylate Synthase)
What is the mechanism of L-Asparaginase? Degrades asparagine. Inhibits protein synthesis in tumors that cant make own asparagine. (USed for Childhood ALL)
What drug(s) is/are used to treat Choriocacrinoma? Methotrexate
What is the mechanism of Bleomycin? Binds DNA as Iron complex --> Free radical damage
What is the major side effect of Dacarbazine? Severe nausea & Vomiting
What drug(s) is/are used to treat AML? 6-Mercaptopurine Cytarabine
What class of drug is 6-Mercaptopurine? Anti-metabolite (Purine analog converted by HGPRT)
What drug(s) is/are used to treat CNS tumors? Hydroxyurea Carmustine
Which antineoplastics cause Hyperuricemia? Mechlorethamine 6-Mercaptopurine
What is the mechanism of Paclitaxel? STABILIZES Microtubules (unlike Vincristine/Vinblastine)
What drug(s) is/are used to treat Breast Cancer? Thiotepa Methotrexate Paclitaxel Tamoxifen
What drug(s) is/are used to treat Pre-malignant skin conditions? 5-Fluorouracil (Topically)
Which antineoplastic incorporates into RNA and is S Phase specific? Cytarabine
What drug(s) is/are used to treat Ovarian Cancer? Paclitaxel Carboplatin
What drug(s) is/are used to treat Head & Neck Tumors? Hydroxyurea Methotrexate
What is the mechanism of Vincristine? Binds tubulin, prevents mitotic spindle formation (M-Phase). Also intercalates, inhibits topo II.
What class of drug is Cytarabine? Anti-metabolite (Incorporates into RNA. S Phase specific)
What drug(s) is/are used to treat Melanoma? Dacarbazine Paclitaxel Hydroxyurea
What is the mechanism of Hydroxyurea? Inhibits Ribonucleoside Diphosphate Reductase --> Inhibits DNA Synth.
What drug(s) is/are used to treat Testicular Cancer? Bleomycin Ifosfamide Vinblastine Etoposide
What are the hepatotoxic neoplastics drugs? Cytarabine L-Asparaginase Etoposide
What is the mechanism of Etoposide? Binds tubulin, inhibits topo II (S phase AND G2)
Created by: sam.mrosenfeld
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