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Keywords-Pharm

QuestionAnswer
A fibers don’t transmit pain, transmit sensations associated with touch and temperature; larger, rapid; block smaller fibers
A delta & C fibers respond stimulation by generating nerve impulses produce pain sensations; smaller
Adverse Effects undesirable or potentially dangerous negative side effects
Affinity attraction of one chemical compound to another
Agonist drugs interact w/receptor sites to cause same activity that natural chemicals cause at site
Anxiolytic alter individuals response to the environment; prevent feelings of tension or fear
Blood dyscrasia bone marrow suppression caused by drug effects
Competitive Antagonist same affinity for receptor as agonist, compete for sites
Noncompetitive Antagonist prevent reaction of another chemical with a different receptor site
Barbiturate once sedative/hypnotic drugs of choice; adverse effects greater newer drugs; anxiolytic drugs
Biotransformation drug metabolism; process drugs changes into new, less active chemicals
Critical Concentration amount of drug needed to cause a therapeutic effect
Chemotherapeutic agents
Dependence physical/psychological; body adjusted to presence of drug; requires drug to function normally
Dermatological reactions adverse reactions involving the skin
Drug allergy body forms antibodies to particular drug causing immune response
Duration the period of time during which something continues
Ergot derivatives cause constriction of cranial blood vessels; systemic adverse effects; rarely used
First pass effect oral drugs lose a large % of dose prior to reaching the tissues
Half life
Hepatotoxicity implies chemical driven liver damage
Hypersensitivity excessive response to primary/secondary effects of drugs
Hypnosis extreme sedation results further CNS depression
Hypnotic cause sleep, minor tranquilizers, produce state of tranquility in anxious patients
Nephrotoxicity the quality of being destructive to kidney cells
Neuroleptic associated neurological adverse effects (major tranquilizers)
Monoamine oxidase inhibitor rarely used;
Onset The length of time needed for a medicine to become effective
Off label uses released drugs used for indication not approved by FDA
Parenteral dose pertaining to a medication administered by a route that bypasses the GI tract, such as a drug given by injection
Peak point at which the desired effect is greatest compared with any side effects.
Pharmocology study of the biological effects of chemicals
Pharmacodynamic how the drug affects the body
Pharmacogenomics study unique difference response to drugs based on genetic makeup
Pharmacokinetics how the body acts on the drug
• Absorption what happens to a drug from time its introduced until it reaches the circulatory system
• Distribution involves the movement of a drug to the body’s tissues
• Biotransformation enzymes liver/cells/GI/blood detoxify chemicals;
• Excretion removal of drug from body
Pharmacotherapeutics branch of pharmacology that uses drugs to treat, prevent, and diagnose disease
Placebo effect more effective if patient thinks it will work
Protein Binding most drugs bound to proteins in the blood; too large enter capillaries; loose/tightly bound effect release time
Receptor theory of drug action Figure 2.1
Synergism drugs that work together to increase drug effectiveness
Selective toxicity (ie: penicillin) effects enzyme system unique to bacteria
Selective serotonin reuptake inhibitor
Spinothalamic tracts transmit information to cerebral cortex
Street drugs nonprescription drugs with no known therapeutic use
Stomatitis inflammation of the mucous membranes; direct toxic reactions drug
Superinfections drugs destroyed NFinfections caused by the usually controlled bacteria
Teratogenicity drugs if reach fetus/embryo can cause death or congenital defects
Tolerance subject’s reaction to the drug decreases so larger doses are required to achieve same effect
Toxicity the quality/condition/degree to which a substance becomes toxic
Triptan new class drugs cause cranial vascular constriction relief of migraine headache
Tricyclic antidepressant reduce reuptake nerves
Tyramine found in food, broken down by MAO enzymes GI tract; absorbed high presence MAOI
Created by: kara1121
 

 



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