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cholinolytics

cholinolytic drugs

QuestionAnswer
Atropine kinetics tertiary amine kinetic:eliminated via metabolism in liver and renal excretion (1/2 life 2 hours), long duration in eye
Atropine clinical uses clinical uses: Opthalmic uses opthalmic: mydriasis and cycloplegia (fundus exams, break symechiae)and othersACLS: stimulate heart rate insecticide and mushroom poisoning GI: decrease GI motility, Lungs: reduce airway secretions.
Atropine toxicity decreased sweating and lacrimation, elevation of BT,: tachycardia, constipation, dry mouth, and blurred vision, mydriasis. CNS: sedation, amnesia, delirium, hrt arrhythmias, and cutaneous vasodila; contra: in glaucoma, children and prostatic hypeplasia
Scopolamine, cyclopentolate, tropicamide clinical uses: Opthalmic uses opthalmic: mydriasis and cycloplegia (fundus exams, break symechiae)and others
Scopolamine kinetics kinetics:faster onset than atropine
other scopolamine uses: uses: motion sickness tertiary amine
cyclopentolate and tropicamide kinetics C:medium duration T: short duration
Oxybutynin, darifenacin, solifenacin, tolterdine clinical uses: clinical uses: Urinary (urge incontinece, bladder spasms) tertiary amine (eye and CNS effects), lipid soluble, well distributed in CNS
Dicyclomin clinical uses: GU (irritable bowel syndrome, minor diarrhea, block muscarinic effects in periphery) tertiary amine: (eye and CNS effects), lipid soluble, well distributed in CNS
parkinson's disease drugs: Benztropine, Biperiden, Orphenadrine, procyclidine, trihexyphenidyl
Quartenary amines: Glycopyrrolate, Mepenzolate, Methscopolamine,Tridihexethyl, Clindinium, Trospium,PropanthelineI, pratropium, Tiotropium
Glycopyrrolate, Mepenzolate, Methscopolamine, Tridihexethyl,Clindinium,Trospium,Propantheline clinical uses: GU (irritable bowel syndrome, minor diarrhea, block muscarinic effects in periphery
Ipratropium, Tiotropium clinical uses: repiratory( asthma and COPD)
nicotinic blockers/ ganglion blockers Hexamethonium, Trimethaphan, Mecamylamine
nicotinic blockers uses: Hypertensive emergencies, induce hypotension
Created by: 925love
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