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Radiobiology 35

Radiobiology chpt 35

Sequence of events that follow high level radiation exposure leading to death within days or weeks acute radiation syndrome
diagnostic xrays result in partial body exposure
Acute clinical symptoms that occur within hours of exposure and continue up to a day or two. Imediate response of radiation sickness prodromal period
period that follows prodromal period and is free of visible effects latent
How long can latent period last from hours or less (5000 rad) to weeks
reduction in white cells of the peripheral blood leukopenia
What syndrome is characterized by reduction in white and red blood cells and platlets hematologic sydrome
Which syndrome causes death because of severe damage to the cells lining the intestines Gastrointestinal (GI) syndrome
Which syndrome causes death because of elevated fluid content of the brain Central nervous system (CNS) syndrome
LD 50/60 whole body radiation dose that causes 50% of subjects to die within 60 days
Acute radiation lethality follows what dose response relationship non linear threshold
as whole body radiation dose increases, average time between exposure and death decreases mean survival time
ld 50/60 dose for human 350
ld 50/60 dose for dog 275
ld 50/60 dose for cockroach 10000
shrinkage of organ or tissue due to cell death atrophy
name 3 examples of tissue that can be affected immediately after exposure gonads, skin, bone marrow
All early radiation responses follow what type of dose response relationship threshold
outer layer of the skin epidermis
middle layer of skin dermis
inner layer of skin subcutaneous
what layer of skin contains basal cells epidermis
stem cells that mature as they migrate to the surface of the epidermis basal cell
sunburn like reddening of the skin erthema
ulceration an denudation of the skin desquamation
clinical tolerance moist desquamation
loss of hair epilation
what type of xrays were used to treat skin diseases grenz rays
What is tinea capitis ringworm
What do ovaries produce and what does it mature into oogonia,ovum
What do testes produce and what does it mature into spermatogonia, sperm
What is the most radiosensitive cell during female germ cell development oocyte in the mature follicle
at what age do the ovaries reach minimum radiosensitivity 20 to 30 years
What does the hemopoietic system consist of bone marrow, circulating blood and lymphoid tissues
All cells of the hemopoietic develop from a single type of stem cell called pluripotential stem cell
where are most circulating blood cells manufactured bone marrow
What are the cell types produce from a single pluripotential stem cell lymphocytes, granulocytes, thrombocytes,erythrocytes
what cells are involved in immune response lymphocytes
what cells are scavenger type of cells used to fight bacteria granulocytes
what cells are involved in clotting of blood to prevent hemorrhage also referred to as platlets thrombocytes
red blood cells that are the transportation agents for oxygen erythrocytes
after exposure what are the first cells to become effected lymphocytes
what is it called when these cells are reduced in number lymphopenia
what are the two most radiosensitive cells in the body lymphocytes and spermatogonia
what is the depletion of platlets called thrombocytopenia
what are the least sensitive blood cells erythrocytes
what is the study of the genetics of cells , particularly cell chromosomes cytogenetics
what type of dose response relationship does radiation induced chromosome aberrations follow nonthreshold
where does the x chromosome originate female
where does the y chromosome originate male
what is the breakage of a chromatid called chromatid deletion
when is chromosome abberation visualized metaphase
what is produced when adjacent chromosomes each suffer one hit and combine dicentrics
single hit abberation are produce with what dose response relationship linear nonthreshold
multiple hit abberation are produced with what dose response relatonship nonlinear, nonthreshold
what are symptoms of prodromal period nausea, vomiting, diarrhea, and leukopenia
what is the dose,prodomal, and latent period for hematologic syndrome 200 to 1000 rad, mild, up to 4 weeks
What happens if dose is not lethal and if dose is lethal in hematologic syndrome recovery begins in 2 weeks and can take up to 6 months, hemorrhage and dehydration occur
what is the dose, prodomal and latent period for gastrointestinal syndromeand when does death occur 1000 to 5000 rad, occurs within hours and last up to a day, 3-5 days, 4 to 10 days
what are the symptoms of central nervous system syndrome nervous, confussion, burning of skin, loss of vision or consciensness
what is the dose, prodomal, and latent period period for cns syndrome and how quickly does death occur excess of 5000 rad, within minutes, up to 12 hours, within a few days
what is desquamation breakdown of tissue
what dose causes skin erythema 500 rad
what dose causes epilation 700 rads
how much of a dose can cause gonadal dysfuntion 10 or more rad minamal, 200 rad temporary infertility, 500 rad sterility
what dose can cause genetic mutations in ovaries and testes 25 to 50 ovaries and 10 rad in testes
What are the parts of lymphoid tissue lymph nodes, spleen, thymus
list the cells from most radiosensitive to least sensitive and the recovery times for each lymphocytes (very slow), granulocytes (2 months), thrombocytes (2 months) and erythrocytes (6 months to a year)
forms of chromosome damage chromatid deletion, dicentric chromosome aberration, reciprocal translocations, and chromosome hit
Created by: subee61