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Pharm Exam 2
Dosing
| Question | Answer |
|---|---|
| Cefazolin (Ancef, Kefzol) | 0.5-2 g IV/IM q8h |
| Cefotetan (Cefotan) | 1-2 g IV/IM q12h |
| Cefoxitin (Mefoxin) | 1 g IV/IM q8h (2 g if severe) |
| Cefuroxime (Zinacef) | 0.75-1.5 g IV/IM q8h |
| Cefotaxime (Claforan) | 1-2 g IV/IM q8h (meningitis: 2 g q6h) |
| Ceftazidime (Fortaz, Tazicef) | 1-2 g IV/IM q8h |
| Ceftizoxime (Cefizox) | 1-2 g IV/IM q8h |
| Ceftriaxone (Rocephin) | 1-4 g IV/IM q24h |
| Cefepime (Maxipime) | 1-2 g IV/IM q12h |
| Tx for febrile neutropenia in oncology pts | Cefepime (Maxipime) 2 g IV/IM q8h |
| Aspiration Pneumo Tx | Clindamycin 600 mg q8h |
| Aspiration Pneumo Tx | Metronidazole 500 mg q6-8h |
| Nosocomial Pneumo Tx | Ceftazidime 1-2 g IVPB q8h |
| Nosocomial Pneumo Tx | Cefepime 1-2 g IVPB q12h plus AG |
| Meningitis Tx | Cefotaxime 2 g IVPB q6h |
| Meningitis Tx | Ceftriaxone 2 g IVPB q12h |
| CAP Tx | Cefotaxime 1 g IVPB q8h (q12h if renal dz/elderly) |
| CAP Tx | Ceftriaxone 1 g IVPB q24h |
| Meningitis Tx regimen addition for infants, elderly or immunocomprised pts | Ampicillin 2 g q6h |
| CAP Tx regimen addition for atypical organism | Zithromax 500 mg PO/IV qd or Biaxin 500 mg PO bid or Doxy 100 mg PO/IV bid |
| Meningitis Tx in post neurological setting caused by staph or G- like P. aeroginosa | Ceftazidime 2 g IVPB q8h |
| Meningitis Tx in post neurological setting caused by staph or G- like P. aeroginosa | Cefepime 1-2 g q8-12h |
| Febrile Neutropenia Tx | Ceftazidime 2 g IVPB q8h |
| Gonorrhea Tx | Ceftriaxone 125-250 mg IM x1 |
| Gonorrhea Tx | Cefixime 400 mg PO x1 |
| Gonorrhea Tx | Cefpodoxime 200 mg PO x1 |
| Gonorrhea Tx | Cefuroxime Axetil 1000 mg PO x1 |
| Surgical prophylaxis | Cefazolin 1 g q8h |
| Bacterial Endocarditis Tx | Ceftriaxone 2 g IVPB q24h |
| Febrile Neutropenia Tx regimen addition for documented G- infection or severe illness | Aminoglycoside |
| VSSA | MIC <4 mcg/ml |
| VISA | MIC 8 mcg/ml |
| VRSA | MIC >32 mcg/ml |
| Tx of MRSA | Vancomycin |
| Vancomycin normal dose | 15 mg/kg (max 2 g/dose) |
| Vancomycin dose for special pop (ex. burn pt) | 19 mg/kg |
| Vanc desired peak | 25-40 mcg/ml |
| Vanc desired trough | 5-10 mcg/ml |
| 1 million Units of Pen | 0.6 g |
| Pen G dose | 1-4 mU q4-6h IV (4-24 mU/day in 4-6 divided doses) |
| Antistaphylococcal penicillins | Cloxacillin, Dicloxacillin, Nafcillin, Oxacillin |
| Extended-spectrum penicillins | Aminopenicillins, Carboxypenicillins, Ureidopenicillins |
| Aminopenicillins | Ampicillin, Amoxicillin |
| Carboxypenicillins | Carbenicillin, Ticarcillin |
| Ureidopenicillins | Piperacillin, Mezlocillin, Axocillin |
| Carbapenems | Imipenem/Cilastin (Primaxin), Merropenem (Merrem), Etrapenem (Invanz) |
| Pen V dose | 250-500 mg PO q6h |
| Benzathine PCN dose: B hemolytic strept pharyngitis | 1.2 mU IM |
| Benzathine PCN G dose: syphilis | 2.4 mU IM q wk x1-3 wks |
| Cloxacillin, Dicloxacillin adult dose | 250-500 mg PO q6h given 1h AC or 2h PC |
| Cloxacillin, Dicloxacillin peds dose | 15-25 mg/kg qd in 4 divided doses |
| Oxacillin, Nafcillin adult dose (serious systemic staph infx) | 1-2 g IV q4-6h |
| Oxacillin, Nafcillin peds dose (serious systemic staph infx) | 50-100 mg/kg qd |
| Amoxicillin dose | 250-500 mg PO tid |
| Ampicillin dose | 250-500 mg PO qid |
| Ampicillin dose: Shigellosis, enterococci, Listeria, monocytogenes, G- cocci & bacilli | 4-12 g IV qd |
| Piperacillin dose | 3-4 g IV q4-6h |
| Ticarcillin dose | 3 g IV q4-6h |
| Ampicillin + Sulbactam = Unasyn | 1.5-3 g IVPB q6h |
| Amoxicillin + Clavulanic acid = Augmentin | 250-500 mg PO tid |
| Augmentin LX dose | 875 mg PO bid |
| Ticarcillin + Clavulanic acid = Timentin | 3.1 g IVPB q6h |
| Piperacillin + Tazobactam = Zosyn | 3.375 g IVPB q6h or 4.5 g IVPB q8h |
| Zosyn dose: nosocomial ventilator asso. pneumonia | 4.5 mg IVPB q6h |
| Imipenem/Cilastin | 250-500 IVPB q6h |
| Merropenem | 1 g IVPB q8h |
| Etrapenem dose: GI infx prophylaxis in hospitalized pts | 1 g IVPB qd |
| AG toxic trough conc. | > 2mcg/ml |
| typical Gentamycin, Tobramycin dose | 5 mg/kg/d |
| AG loading dose | 2 mg/kg |
| AG maintenance dose | 1.5 mg/kg |
| AG: CrCl > 100 ml/min | use q8h dosing |
| AG: CrCl 50-100 ml/min | use q6h dosing |
| AG desired trough | < 2 mcg/ml |
| AG desired peak | 5-10 mcg/ml |
| Streptomycin adult dose | 0.5-1 g IV/IM qd |
| Streptomycin peds dose | 7.5-15 mg/kg IV/IM qd |
| Streptomycin: Nontuberculous infx | adults: 1 g qd, children: 15 mg/kg IM qd w/ tetracycline PO |
| Gentamycin: meningitis caused by G- | 1-10 mg IT qd |
| Amikacin dose | 15 mg/kg qd in 2-3 divided doses (500 mg IV/IM q12h) |
| Neomycin: bowel surgery | 1 g PO q6-8h x24-48h w/ 1 g erythromycin base |
| Neomycin: hepatic coma | 1 g PO q6-8h |
| 1st gen quinolones | Nalidixic acid, Cinoxacin |
| 2nd gen quinolones | Norfloxacin, Ciprofloxacin, Lomefloxacin, Ofloxacin, Enoxacin |
| 3rd gen quinolones | Sparfloxacin, Gatifloxacin, Grepafloxacin, Levofloxacin, Moxifloxacin |
| 4th gen quinolones | Trovafloxacin |
| Naldixic acid (NegGram) | 1 g PO qid |
| Cinoxacin (Cinobac) | 250-500 mg PO bid (1 g qd) |
| Norfloxacin (Noroxin): uncomplicated UTI | 400 mg PO bid x7-10d, 1h AC or 2h PC |
| Norfloxacin (Noroxin): complicated UTI | 400 mg PO bid x10-21d, 1h AC or 2h PC |
| Ciprofloxacin (Cipro) | 250-750 mg IV q12h (typically 400 mg IVPB bid) |
| Lomefloxacin (Maxaquin) | 400 mg PO qd |
| Ofloxacin (Floxin) | 200-400 mg q12h |
| Enoxacin (Penetrex): gonorrhea | 400 mg PO x1 |
| Enoxacin (Penetrex): UTI | 200-400 mg PO bid |
| Sparfloxacin (Zagam) | 400 mg PO loading dose then 200 mg qd x10d |
| Gatifloxacin (Tequin) | 400 mg IV/PO qd |
| Grepafloxacin (Raxar) | 400-600 mg PO qd |
| Levofloxacin (Levaquin): general dose | 250-500 mg PO/IV qd |
| Levofloxacin (Levaquin): complicated skin infections | 750 mg PO/IV qd x7-10d |
| Levofloxacin (Levaquin): severe respiratory infx | 750 mg PO/IV qd x5d |
| Moxifloxacin (Avelox) | 400 mg PO/IV qd (decrease in HEPATIC dz) |
| Trovafloxacin (Trovan) | 200 mg PO qd, 200-300 mg IV qd |
Created by:
lisaschavrien
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