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Pharm NMJ Drugs
Pharm autonomics
| Question | Answer |
|---|---|
| Direct Acting Muscarinic Agonists | Bethanechol, Pilocarpine |
| Indirect Muscarinic Agonists? | Anticholinesterases: Physostigmine "" w/ Nicotinic Receptor agonist effects: Neostigmine, pyridostigmine, edrophonium |
| Bethanechol | Direct musc. agonist Treats GI atony, Urine retention GI: improve tone, peristalsos, sphinctor relaxation Bladder: Contract fundus, relax spjincter --> leads to urination |
| Pilocarpine | Direct Musc. Agonist Treats glaucoma, causes miosis which relieves congestion by uncovering canal of schlemm ports Tox: Overaccomidation (miosis) |
| Methacholine | Direct Musc. Agonist Used for Challenge type diagnosis of asthma and pulmonary function testing |
| Physostigmine | Anticholinesterase; indirect Muscarinic agonist crosses BBB to enter CNS |
| Echothiophate | organo toxin used for long term glaucoma relief Tox: drooling, wheezing, defecation |
| Atropine | Muscarnic Antag from the atropa belladonna aka deadly nightshade. Reversible blockade of cholinomimetic action |
| Antag effects of Atropine and Scopolamine | M2 antag: Decrease negative action at pacemaker of heart ( allows increase in HR) M3 antag: decrease miosis, bronchoconstriction, salvation, sweating, GI function, Urinary function |
| Atropine Tox | Hot as a pistol: hyperthermia (decraesed sweating) Red as a beat: vasodilation Dry as a bone: decreased secretions Blind as a bat: pupil dilation/ lens accomidation blcoked Mad as a hatter: sedation/ hallucinations Constipation: decreased GI function |
| N-N- receptor | Nicotinic receptor has 2 agonist binding sites. Agonist binding results in opening of channel which allows flow of NA/K. Results in depolarization of nerve cell of neuromuscular end plate ( prolonged activity of N receptor abolishes the effector response) |
| Ganglionic blockade | Nicotinic (N) Rs in both SANS and PANS are blocked - these are essential for transmission of Ach at the ganglia |
| Mecamylamine | Nn ganglionic Blocker Decreases SANS control of TPR or SVR Decreases BP SE:CNS: sedation, Eye: cycloplegia, decraeses GI motility, urinary retention |
| Anticholineesterases | Physostigmine, neostigmine, pyridostigmine, echothiphate, sarin, edrophonium Uses: diagnosis of Myasthenia Gravis Reverse Curare, atropine tox ALL Anti-ACHE are indirect acting Nn agonists Tox: muscle paralysis |
| Curare | Competitive antagonist against Ach at NMJ |
| Sarin | Nerve gas, Anti- ACHE nicotinic twitching, SANS overcomes PANS, muscle weakness and loss of reflexes, Death due to respiratory failure. Diaphragm paralysis and CNS center failure. Treat w Atropine and Pralidoxime ( cholinesterase reactivator |
Created by:
stedford5
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