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IOS 9 Exam 2

Urinary Incontinence/BPH

QuestionAnswer
Risk foctors for Uninary Incontinence Immobility, Gender (female), parity (childbirth), UTI, Menopause, GU surgery, lack of pastpartum exercise, various medications
Clinical, Psychological, and social impact of Urinary Incontinence Rashes, pressure sores, skin&UTi's, ordor, restricted activities, embarrassment, isolation, depression, sexual dysfunctio, institutionalation
Stress Incontinence cause Dysfunction of the urethral spincter leading to loss when intra-abdominal pressure increases
Stress Incontinence S/S Pressure cause release-coughing, sneezing, bending, lifting, and less common at night since muscle are relaxed and no pressure exerted
Detrusor Instability/OVeractive bladder and Urge Incontinence cause CNS dysregulation such as stroke, Parkinsons disease, alzehimers disease-No warning
Detrusor Instability/OVeractive Bladder and Urge Incontinence S/S No warning Voiding-No characteristic features on PE, s/s -Nocturia, frequent small volume voiding
Overflow Incontinence causes Bladder outlet is obstructed, spinal cord lesions, Diabetic neuropathy, muscle relaxants, calcium channel blockers, anticholinergics
Overflow Incontinence S/S Palpable and percussable bladder, that is tender. Low flow rates, and post-void residual volume
Functional Incontinence cause Musculoskeleta limitations, unfamilular setting
Iatrogenic Incontinence cause Drugs: diuretics, hypnotics, muscle relaxants, alpha 1 agonist (pseudoephedrine), alpha antagonsts (terazosin, prazosin), anticholinergics, calcium channel blockers
Treatment of Detrusor instability Anticholinergis decrease detrusor contractions, and increase bladder capacity to decrease urgency. Darifenacin, Solifenacin, Tropium, Tolterodine, Tolterodine LA, Oxybutin (pathch and XL and generic)
Side effects of anticholingergics Dry mouth, constipation, cognitive impairment
Treatment of Stress Incontinence Kegel exercises, topical estrogens/estring for atrophic vaginitis, pseudoephedrine, or duloxetine will all help to increase resistance to sudden intra-abdominal pressure
Treatment of Overflow incontinence Improve drainage of bladder by giving: alpha antagonist (prazosin, terazosin,doxazosin, phenoxybenzamine, bethanechol) or 5 alpha reductase inhibitor (Proscar, avodart)
Side effects of duloxetine HA, fatigue, insomnia, constipation, dry mouth, dizziness, increased BP
Side effects of alpha antagonists Hypotension, tachycardia, impotence
Treatment for Functional Incontinence Remove underlying cause, get bedside commode, schedule bathroom visits, remove sedatives
When behavioral interventions are used in combination with medication therapies Excellent results. Medications alone have been shown to be minor benefit especially in nursing home patients
What is the role of alpha antagonists in Overflow incontinence- bladder obstruction alpha 1 receptors inhibit the contraction of prostatic smooth muscle thus relieve bladder obstruction.
Contraindications of alpha antagonist Pregnancy, blood donation for 6 months
What is the role of 5 alpha reductase inhibitors in bladder obstruction Finasteride and dutasteride reduce DHT levels thus reduce the size of the prostate. Useful in men with enlarged prostrates requires 3-6 months but no change in urine flow and less symptom relief than alpha-blockers
AUA symptoms Index for Mild 0-7
AUA symptoms Index for Moderate 8-19
AUA symptoms Index for severe 20-35
Combination therapy for overflow incontinence when patient has Alpha antagonist & 5 alpha reductase inhibitor if: Lower urinary tract symptoms and enlarged prostrate
Symptoms improvement from alpha antagonist should occur days to weeks
Pharmacological selectivity of an alpha antagonsit means No BP effects and selectivly inhibits alpha 1
Functional selectivity of a alpha antagonsit means Low peripheral BP effects although it is designed as a alpha 1
No uroselectivity means Have BP effects=terazosin and doxazosin
Extended release formulations of alpha antagonists Alfuzosin, and Tamsulosin
Monitoring paramenters for overflow incontience BP, volume, orthostatic hypotension
Psuedoephedrine not recommended for Stress incontinence patients who have HTN
Drugs that cause stress incontinence terazosin, prazosin, anticholinergics, muscle relaxants
Created by: liza001
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