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Pharm - Thyroid

Drugs for Tx, Patho, AP

QuestionAnswer
Condition: Dwarfism Severe mental retardation Cretinism (Hypothyroidism)
Condition: Slowed body metabolism Slurred speech Bradycardia weight gain Low body temperature Intolerance to cold Myxedema (Hypothyroidism)
Blood tests used to Dx thyroid problems specifically Hypothyroidism? Serum levels of circulating T3 and T4 hormones
Drug od choice used to Tx hypothyroidism by increasing T4 hormone? Synthetic levothyroxine
What is the brand name for Synthetic levothyroxine? Synthroid, Levoxyl
Side effects of Synthetic levothyroxine(Synthroid)? Hyperthyroidism Dose related May occur 1 to 3 weeks after changes in therapy
Drug interactions that may cause concern for Synthetic levothyroxine? Warfarin Digoxin Estrogens Diabetes medications
Some clinical Signs/Symptoms of Hyperthyroidism? Rapid, bounding pulse (even sleeping) Cardiac enlargement Palpitations Dysrhythmias Nervous Easily agitated Tremors Low grade fever Hyperactive reflexes Insomnia Intol. heat Warm, flushed moist skin, Sweating
Different treatments for Hyperthyroidism? Subtotal thyroidectomy Radioactive iodine Antithyroid medications
Destroys the hyperactive thyroid tissue, with essentially no damage to other tissues in the body Iodine – 131
Radioactive isotope of iodine Absorbed into thyroid in high concentrations Iodine – 131
Block synthesis of T3 and T4 in the thyroid gland Do not destroy what is already there Few days to 3 weeks before symptoms improve Antithyroid agents
Prophlthiouracil (PTU, Propacil) Methimazole (Tapazole) What class of drugs are these? Antithyroid Agents
Some side effects of antithyroids? Purpuric, maculopapular rash, Headaches, loss of taste, bone marrow suppression, hepatotoxicity
Created by: live2havefun
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