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Heiman.pharm.vasc12

Low Molecular Weight Heparins (LMWHs)

QuestionAnswer
Mechanism Inhibition of clot formation higher up the clotting cascade
Kinetics Not absorbed orally, given SC Relatively long half-life Extensive renal clearance Dosage adjustment in renal disease needed
Adverse Effects Bleeding Thrombocytopenia Pulmonary edema Fever Peripheral edema
Cautions Use cautiously with other blood thinners No need to follow aPTT Can get Anti-Xa levels but it is not routine practice Protamine cannot be used for overdosage
Names Enoxaparin (Lovenox)‏ Dalteparin (Fragmin)‏ Tinzaparin (Innohep)‏ Fondaparinux (Arixtra)‏ Not technically a LMWH Direct Anti-Xa inhibitor
Created by: DianaB
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