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Heiman.pharm.vascev9

Clopidogrel

QuestionAnswer
Mechanism Inhibits the binding of adenosine diphosphate to the receptor on the platelets preventing the activation of the glycoprotein IIb/IIIa complex This complex promotes platelet aggregation Inhibition is irreversible
Ticlopidine (Ticlid) Mechanism the same as clopidogrel Not used very much any more due to the possibility of life-threatening agranulocytosis
Kinetics About 50% bioavailable Hepatic metabolism Renal clearance
Adverse Effects Bleeding TTP – rare Nausea Diarrhea Rash Fatigue Palpitations Chest pain
Cautions Liver disease Other anticoagulant / antiplatelet drugs
Created by: DianaB
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