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Heiman.pharm.vascev5

Selective Cholesterol Absorption Inhibitor

QuestionAnswer
Mechanism Acts on the brush border of intestinal epithelial cells to selectively inhibits the absorption of cholesterol from dietary and biliary sources
Effects Decreased LDL Decreased triglycerides Increased HDL
Kinetics Little oral absorption Enterohepatic recirculation Metabolized in liver and small intestine to active drug Eliminated in feces
Cautions Not recommended with hepatic insufficiency
Adverse Effects Fatigue Cough Abdominal pain Diarrhea Dizziness
Drug Interactions Fibric acid derivatives Increased levels of ezetimibe Bile acid sequestrants Decreased ezetimibe levels Cyclosporine Increased ezetimibe levels
Names Ezetimibe (Zetia)‏ Vytorin (ezetimibe + simvastatin)‏
Created by: DianaB
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