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heiman.pharm.vascev3

Bile Acid Sequestrants

QuestionAnswer
Mechanism Bind to bile acids and increase their excretion leading to a diversion of cholesterol into bile acid synthesis This leads the liver to increase the catabolism of LDL to get the cholesterol
Effects Decreased LDL Increased triglycerides No change in HDL
Kinetics Not absorbed orally No metabolism Completely excreted in feces Maximal effect seen in 1 month
Cautions Contraindicated in: Biliary obstruction Patients with phenylketonuira should avoid Questran light, which contains aspartame May interfere with the absorption of fat soluble vitamins (A, D, E, and K)‏
Adverse Effects Fatigue Weight loss/gain Chest pain Malabsorption of nutrients and medications
Drug Interactions Decreased absorption of most medications Take other medications 1 hr before or 4 hr after sequestrants
Names Cholestyramine (Questran, Questran Light)‏ Colestipol (Colestid)‏ Colesevelam (WelChol)‏
Created by: DianaB
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