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Fibric Acid Derivatives

Mechanism Increased lipoprotein lipase activity which leads to increased catabolism of VLDL. May also: Suppress lipolysis in adipose tissue. Decrease free fatty acid flux. Lower the rate of triglyceride synthesis. Decrease TG 20-50%. Increase HDL 15-35%.
Adverse effects Hepatotoxicity Cholelithiasis Fatigue Rash Atrial fibrillation Abdominal pain Nausea/vomiting Anemia Increased glucose Rhabdomyolysis Decreased renal function
Monitoring Lipid profile. Gemfibrozil. CBC q3months for 12 months. LFTs at baseline, 6 weeks, 12 weeks, and twice yearly thereafter.
Drug Interactions Statins. (Except for Fenofibric Acid). Increased risk of rhabdomyolysis. Warfarin. Increased anticoagulation response.
Names Gemfibrozil (Lopid)‏. Fenofibrate (Tricor, Triglide, Lipofen, Antara)‏. Fenofibrate micronized (Lofibra)‏.
Created by: DianaB



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