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Heiman.pharm.Vasc ev
Cardiovascular Events.Angina
| Question | Answer |
|---|---|
| Cardiovascular events | Angina Myocardial Infarction (MI) |
| Epidemiology | Around 7 million Americans suffer from angina Risk of developing ischemic heart disease differs by region of the world |
| Epidemiology | Japan and France have low rates Finland, Northern Ireland, Scotland, and South Africa have high rates Numbers of vessels obstructed is a predictor of mortality LAD has poorer prognosis |
| Pathophysiology | Atherosclerosis Fatty streak LDL Smooth muscle cells Calcification Thrombus |
| Pathophysiology | Increased Myocardial Oxygen Demand Exercise Mental stress Normal fluctuations in HR and BP Decreased myocardial oxygen supply Vasospasm Platelet plugging Thrombus |
| Pathophysiology | Catecholamine release Released in response to stress Leads to increased HR, BP, force of contraction This leads to increased oxygen demand |
| Angina | Myocardial ischemia that occurs when oxygen demand outstrips oxygen supply Reversible Lasts from 0.5-30 minutes |
| Stable angina | Reproducible symptom pattern No change in frequency, duration, or precipitating factors in last 2 months |
| Unstable angina | Change in pattern of ischemia New onset, onset with less exertion, or pain at rest Patient should be admitted |
| Variant (Prinzmetal’s) angina | Coronary artery spasm Rare |
| Silent ischemia | Asymptomatic episodes detected by ECG or other diagnostic methods |
| Precipitating Factors | Relationship to exercise Cold environment Walking against the wind Walking after a large meal Fright, anger |
| Quality | Sensation of pressure or heavy weight on chest Burning sensation Feeling of tightness Shortness of breath Visceral quality (deep, heavy, squeezing, aching) |
| Radiation | Medial aspect of left arm Left shoulder Jaw Occasionally right arm |
| Location | Sternum Can be anywhere between epigastrium and pharynx May be limited to left arm and shoulder Lower cervical or thoracic spine Left interscapular or suprascapular area |
| Differential Diagnosis | Esophageal reflux Peptic ulcer Biliary disease Cervical disc disease Hyperventilation Musculoskeletal pain Pulmonary |
| Treatment | Modification of risk factors Decrease weight Stop smoking Increase activity Normalize blood pressure Normalize blood lipid levels Increase oxygen supply |