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Heiman.pharm.Vasc ev

Cardiovascular Events.Angina

QuestionAnswer
Cardiovascular events Angina Myocardial Infarction (MI)
Epidemiology Around 7 million Americans suffer from angina Risk of developing ischemic heart disease differs by region of the world
Epidemiology Japan and France have low rates Finland, Northern Ireland, Scotland, and South Africa have high rates Numbers of vessels obstructed is a predictor of mortality LAD has poorer prognosis
Pathophysiology Atherosclerosis Fatty streak LDL Smooth muscle cells Calcification Thrombus
Pathophysiology Increased Myocardial Oxygen Demand Exercise Mental stress Normal fluctuations in HR and BP Decreased myocardial oxygen supply Vasospasm Platelet plugging Thrombus
Pathophysiology Catecholamine release Released in response to stress Leads to increased HR, BP, force of contraction This leads to increased oxygen demand
Angina Myocardial ischemia that occurs when oxygen demand outstrips oxygen supply Reversible Lasts from 0.5-30 minutes
Stable angina Reproducible symptom pattern No change in frequency, duration, or precipitating factors in last 2 months
Unstable angina Change in pattern of ischemia New onset, onset with less exertion, or pain at rest Patient should be admitted
Variant (Prinzmetal’s) angina Coronary artery spasm Rare
Silent ischemia Asymptomatic episodes detected by ECG or other diagnostic methods
Precipitating Factors Relationship to exercise Cold environment Walking against the wind Walking after a large meal Fright, anger
Quality Sensation of pressure or heavy weight on chest Burning sensation Feeling of tightness Shortness of breath Visceral quality (deep, heavy, squeezing, aching)‏
Radiation Medial aspect of left arm Left shoulder Jaw Occasionally right arm
Location Sternum Can be anywhere between epigastrium and pharynx May be limited to left arm and shoulder Lower cervical or thoracic spine Left interscapular or suprascapular area
Differential Diagnosis Esophageal reflux Peptic ulcer Biliary disease Cervical disc disease Hyperventilation Musculoskeletal pain Pulmonary
Treatment Modification of risk factors Decrease weight Stop smoking Increase activity Normalize blood pressure Normalize blood lipid levels Increase oxygen supply
Created by: DianaB
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