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Depression

QuestionAnswer
Tricyclic antidepressants (TCAs) MOA Block reuptake of NE and 5HT (serotonin)
TCAs AE ORTHOSTATIC HYPOTENSION, ANTICHOLINERGIC EFFECTS, sedation, CARDIAC TOXICITY, SEIZURES,
TCAS INTER MAOIS, LINAZOLID, ANTICHOLINERGICS, ANTIDYSRHYTHMICS, PIMOZIDE
TCAS overdose treatment gastic lavage, physostigmine, propranolol, lidocaine, and pheyntoin
SSRI MOA selective inhibition of serotonin reuptake
SSRI AE sexual dysfunction, GI, SEROTONIN SYNDROME, BLEEDING DISORDERS, HYPONATREMIA
SSRI INTER MAOI, LINAZOLID, lithium, NSAIDS, WARFARIN, TCAs
Which is the most popular anti-deppressant? SSRI
SSRI with the longest half life Fluoxetine (the flu always lasts a long time)
SSRI that has an increase in half life with the elderly Escitalopram
SNRIs MOA block NE and 5HT
SNRI other cannot be cut/crushed/chewed
Venlafaxine/desvenlafaxine class SNRIs
Venlafaxine/desvenlafaxine EA DIASTOLIC HTN, hypercholesterolemia, anorexia, sweating
Dulozetine AE LIVER TOXICITY, increase B/P, NARROW ANGLE GLAUCOMA
Venlafaxine OTHER dose adjust with the elderly
Dulozetine Monitor LFT
MOAIs MOA irreversible inhibition of MAO
MOAIs AE CNS stimulation, orthostatic hypotension SEROTONIN SYNDROME, HYPERTENSIVE CRISIS,
MOAIs INTER THYRAMINE (increase risk of hypertensive crisis)
Bupropion Class Atypical Antidepressant
Bupropion AE SEIZURE, constipation, weight loss
Bupropion INTER EtOH, MAOIs
Bupropion Other Does not cause weight gain or sexual dysfunction
Created by: jyche
Popular Pharmacology sets

 

 



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