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rhodes 3

antipsychotics and antidepressants

QuestionAnswer
prototype for typical antipsychotic? haloperidol (haldol)
What is the best target receptor for antipsychotic drugs? D2 dopamine receptor
Name all typical antipsychotic drugs total of 9? chlorpromazine (thorazine), fluphenazine (prolixin), halaoperidol (haldol),loxapine (loxitane),molindone (moban), perphenazine (trilafon),pimozide (orap),thioridazine(mellaril),thiothixene (navane)
Name all atypical antipsychotic durgs total of 7? aripiprazole (abilify),clozapine (clozaril),olanzapine (zyprexa),quetiapine (seroquel),paliperidone (invega), risperdone (risperdal),ziprasidone(geodon)
dopamine receptor blockade: which drugs work better typical or atypical? typical
Serotonin receptor blockade uses atypical or typical drugs? atypical>haloperidol>chlorpromazine
alpha adrenergic receptor blockade uses typical or atypical drugs? typical>atypical chlorpromazine>thioridazine>>haloperidol
muscarinic receptor blockade uses atypical or typical drugs? typical>atypical thioridazine>chlorpromazine
clinical uses of antipsychotics? schizophrenia, acute psychosis, mania, bipolar disorder, psychotic depression, n/v, tourette's syndrome
Which causes more extrapyramidal symptoms? typical>>atypical
What are the extrapyramidal symptoms? parkinson like, akathesia, tardive dyskinesia
What are some symptoms of tardive dyskinesia? mouth, choreiform movements, perioral tremors
Name 5 other extrapyramidal sxs? cns(sedation, seizures), ans (anticholinergic), cvs(ortostatic hypotension, QT prolongation),Endocrine, allergic rxn
Name the three clinical features of depression? psychological, physiological, cognitive
Name three MAO drugs used to treat depression/mania phenelzine (nardil),selegiline (eldepryl),tranylcypromine (parnate)
How do tricylic antidepressants work? block reuptake of NE from CNS
Give examples of TCA's amitriptyine(elavil),clomipramine(anafranil),desipramine(norpramin),doxepin(sinequan),imipramine(tofranil),protriptyline(vivactil),trimipramine(surmontil)
How does SRI's work? block reuptake of serotonin
what is the prototype for sri? fluoxetine(prozac)
Name SRI drugs? citalopram (celexa),escitalopram(lexapro),fluoxetine(prozac),fluvoxamine(luvox),paroxetine(paxil),sertaline(zoloft)
What does selective serotonin-NE-reuptake inhibitors do? block serotonin and NE
Name the 3 SNRI's desvenlafaxine(pristique),duloxetine(cymbalta), vanlafaxine(effexor)
Tetracyclics and Unicyclics what three block serotonin and NE reuptake and which drug is a serotonin antagonist? 3:amoxapine(asendin),bupropion(wellbutrin),mirtazapine(remeron) 1:trazadone(desyrel)
what is the MOA of antidepressants and antimanic agents? block reuptake of catecholamine which increase concentration of catecholamines in synapses of various brain areas.
What are some clinical uses for AD and AM? depression, anxiety, premenstrual dysphoric disorder, smoking cessation, pain disorders
What are some adverse effects of AD and AM drugs? CNS-suicidal thoughts, insomnia to sedation N,V,D ANS-anticholinergic CVS-orthostatic hypotension,arrhythmias other-sexual
What is the drug interaction of Imipramine(TCA)? block antihypertensive of guanethidine (Ismelin)potientiate effects of CNS depressants and anticholinergics
What is the drug interaction of SSRI's? inhibit cytochrome p450. It will increase plasma level.
What is the drug interaction of MAO inhibitors? inhibit p450. pt. should avoid eating foods containing tyramine.
If a pt. is on a MAO an consumes to much tyramine what would the outcome be? hypertensive crisis. tyramine causes increase NE release and MAO block NE breakdown, and increases sympathetic outflow and increase bp.
What are the clinical features of mania? euphoria,irritability,severe panic
What is the golden standard for treatment of mania? lithium
what does lithium do? decreases NE release from brain
what are other drugs that could treat mania? atypical antipsychotics, carbamazepine(tegretol),valproic acid(depakene),topiramate(topamax)
Created by: tessa83
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