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Heiman.pharm.HTN.2

Potassium Sparing Diuretics

QuestionAnswer
Potassium Sparing Diuretics: Na-channel blockers (Often used in combination with other diuretics.) MECHANISM OF ACTION: Inhibition of Na channel in the collecting duct. Results in excretion of Na and retention of K.
Potassium Sparing Diuretics: Aldosterone Antagonists Mechanism of action: Aldosterone receptors located in the collecting ducts. Activation of these receptors leads to: Activation of inactive Na channels Stimulation of the production of more Na channels.
Potassium Sparing Diuretics: Aldosterone Antagonists (Mechanism cont'd) Competitive inhibition of these receptors leads to increased Na excretion.
Kinetics: Good oral absorption. Liver metabolism.
Adverse Effects: Hyperkalemia. Hypotension. Nausea/vomiting. Weakness. Headache. Fatigue. Gynecomastia - spironolactone.
Cautions Renal insufficiency Diabetes Those on ACE inhibitors, NSAIDS, or K supplements.
Names Na channel blockers: Triamterene (Dyrenium)‏ Amiloride (Midamor)‏ Aldosterone antagonists: Spironolactone (Aldactone)‏ Eplerenone (Inspra)‏
Diuretic combinations Hydrochlorothiazide/amiloride (Moduretic)‏ Hydrochlorothiazide/spironolactone (Aldactazide, Spirozide)‏ Hydrochlorothiazide/triamterene (Dyazide, Maxzide)‏
Created by: DianaB
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