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3rd yr Pharm micrbls

3rd year Pharmacology course antimicrobial drugs

Chloramphenicol Unclassified(atypical)- Peptidyl Transferease inhibitor to inhibit protein synthesis
Erythromycin Macrolide- 50S ribosome subunit binding & used for protein synth inhibition- Aminoacyl translocation (tRNA-rRNA transfer) inhibition.
Streptomycin First Aminoglycoside- S12-protein of 30S ribosome subunit binding, interfering with formyl-methionyl-tRNA binding (--X protein synth)
Sulphanilamide Sulphonamide- Dihydropterate synthetase inhibitor (for folic acid synth)
Tetracycline Tetracycline family- binds to 16S-part of 30S ribosome subunit & reversibly inhibits aminoacyl tRNA from binding to the A-site
Nystatin Similar to Tetracyclines- Ergosterol-binding forms pores that lea to K+ loss & death.
Ciprofloxacin Fluoroquinolone- for both G-/+ Inhibits DNA Gyrase in G- & topoisomerase II/IV in G+. Inhibits DNA replication & reading.
Clindamycin
Gentamicin
Trimethoprim
Fluoroquinolones (Ciprofloxacin)- Inhibit DNA gyrase in G- or topoisomerase II/IV in G+. Inhibits DNA replication & reading.
Lincosamides (class)
Macrolides
Aminoglycosides
Tetracyclines
Penicillin Beta-lactam- DD-transpeptidase inhibition for peptidoglycan-crosslinking inhibition
Created by: seeriktus
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