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Autonomics-1.4

Pharmocology-Autonomics1.4/chemicaltransmission&drugactionCNS

QuestionAnswer
fast neurotransmitters? ligand-gated ion channels (GABA and glutamate)
slow neuroransmitters? G-protien coupled receptors (DA and neuropeptides)
which act through both g-protien and ligand gated ion channels? Ach, 5HT, and glutamate
glutamate? excitatiry, high in CNS and little elswhere, Ca dependent excytosis.
what are the 4 EAA receptors? NMDA, AMPA, Kainite, Metabotropic. All are ligand gated, except metabotropic is g-protien
NMDA receptor requires what modulators? glycine and glutamate to control Ca entry
NMDA and AMPA facilitation? act in sites different than glutamate binding site. some agents block glycine from binding (antagonist)
what is ketamine? anesthetic, blocks the channel itself so no Ca can get through.
GABA? inhibitory neurotransmitter in the brain. formed from glutamate, two types of receptors, GABA A and B.
GABA A receptor? postsynaptic, coupled to Cl channel, opening reduces excitability.
what drugs react with GABA A receptors? benzodiazepines (agonist that bind to accessory binding site), picrotoxin (convulsants block anion channel), neurosteriods (progesterone metabolites), CNS depressants (barbiturates facilitate GABA)
GABA B receptors? g-protien coupled, inhibit cAMP formation. pre and post synaptic inhibition by inhibiting Ca channel opening, and inc K conducance.
Baclofen? GABA B receptor agonist to treat spasticity. (antagonists are not of clinical use)
Glycine? neurotransmitter in SC acting on it's own receptor, functionaly resemble GABA A receptors.
strychnine? competative glycine antagonist, convulsant drug
Tetanus toxin? interfere with glycine release
Created by: lmh9p4
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