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Opiods,Opiates
Pharmacology, Medicinal
| Question | Answer |
|---|---|
| An unpleasant sensory and emotional experience with actual or potential tissue damage or described in terms of damage | Pain |
| Analgesia is defined as | Absence of Pain |
| What are the 3 major fibers of pain? | C fibers A Delta A Beta |
| Are C fibers myleniated or non-myleniated? | Unmyleniated |
| Refers to natural, semi-synthetics, and synthetic drugs | Opioids |
| Refers to natural compounds within the opium poppy plant | Opiate |
| 4 Types of Receptors | Mu, Delta, Kappa, Sigma |
| Which type of receptor is non-opioid? | Sigma |
| Beta-endorphin | High Affinity for Mu & Delta Little Activity for Kappa |
| Met-enkephalin/Leu-enkephalin | High affinity for Delta Receptors Moderate for Mu Low for Kappa |
| Dynorphin-A | High affinity for Kappa Receptors Moderate for Mu |
| Endorphin | High affinity for Mu Receptors |
| Mor Receptor | Supraspinal Analgesia, Euphoria, Sedation |
| Kappa Receptor | Spinal Analgesia, Sedation, Dysphoria |
| Phenanthrenes (Strong Agonist) | Morphine (Roxinal, MS Contin) Hydromorphone (Dilaudid) Oxymorphone (Numorphan) Heroin (Diamorphine, Diacetylmorphine) |
| Phenylheptylamines (Strong Agonist) | Methadone (Dolophine) |
| Phenylpiperidines (Strong Agonist) | Meperidine (Demerol) Fentanyl (Sublimaze) Sufentanil (Sufenta) Alfentanil (Alfenta) Remifentanil (Ultiva) |
| Morphinans (Strong Agonist) | Levorphanol (Levodromoran) |
| Phenanthrenes (Moderate Agonist) | Codeine, Oxycodone, Dihydrocodeine, Hydrocodone, Tramadol |
| Phenylheptylamines (Moderate Agonist) | Propoxyphene (Darvocet) |
| Phenylpiperidines (Moderate Agonist) | Diphenoxylate & Difenoxin |
| Antagonist (Pure) | Naloxone, Naltrexone,Nalmefane |
| Mixed Agonist & Antagonist (Phenanthrenes) | Nalbuphine, Buprenorphine |
| Mixed Agonist & Antagonist (Morphinans) | Butorphanol (Stadol) |
| Mixed Agonist & Antagonist (Benzomorphans) | Pentazocine (Talwin) Dezocine (Dalgan) |
| Mixed Agonist & Antagonist have the ability to bind to receptors | Mu (antagonist) Kappa (agonist) |
| Buprenorphine binds to the receptors | Mu (Agonist) Kappa (Antagonist) |
| Lofran (an antiseritonin drug) is used for | post operative nausea & vomiting |
| Pruritus usually happens where | injection site into spinal cord |
Created by:
dbpharm13
Popular Pharmacology sets