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chapter 2
| Question | Answer | ||
|---|---|---|---|
| ANTIBIOTICS | kills cells,during mitosis(replication);kills disease microorganisms | ||
| DISTRIBUTION | after a drug is absorbed,the transportationof that drug from the bloodstream to the body tissues and intended site of action. | Some drugs tend to collect in certain organs or tissues,called reservoirs.If drugs do collect in reserviors,they are released into the body more slowly than drugs that are evenly distributed at the start. | |
| PHARMACOKINETICS | the study of a drug during,absorption,distribution,metabolism,and excretion. It refers to how the body handles a drug from the site of administration to the elimination of the drug. | ||
| DRUG ACTION | are chemical that are known to have specific effects on the body.When one of these chemicals comes in contact with body cells,it causes changes in the cell molecules; they usually speed up or slow down the ordinary processes that the cells carry out. | antihistimines slow the body's natural reactions to irritation,stimulants speed up the energy-producing functions of cells.Drugs are treated just like any other substance that enters the body,such as food,drink and air. | |
| SUBLINGUAL | under the tongue | Nitroglycerin | |
| BUCCAL | in the cheek | Methylthestosterone | |
| ORAL | in the stomach/intestine | Ibuprofen | |
| IM | in the muscle | Meperidine | |
| IV | (fastest);in the blood stream | Antibiotics,antineoplastics | |
| SUBCUTANEOUS | under the skin(fat) | Epinephrine,insulin | |
| TOPICAL | Through the skin | Nitrodisc,Hydrocotisone ointment | |
| RECTAL | in the rectum | Bisacodyl | |
| EXCRETION | the bodys way of removing the waste products of ordinary cell process;excreted in the same way as other waste products,most drug leave the body thru the kidneys and large intestine | in the kidney the blood is filtered and liquid waste products collect in the form of urine,in the large intestine,feces.Some drugs are excreted in the sweat glands,hair and milk glands. | |
| FACTORS AFFECTING DRUG ACTION | route of administration,time of day,the number of doses,diet, and enviornmental conditions. | ||
| AGE | infants body systems are not fully developed,older aldult may not function as efficiently as in middle aged,older adults have decreases in kidney and liver function,in which result in failure to completely metabolize or excrete drugs. | ||
| SIZE | a person's size and whether he or she is fat or lean have a bearing on drug action | an obese individual requires a higher dose of a drug to achieve the desired result because of the high precentage of body fat. | |
| DIET | combining certain drugs with certain foods can alter the drug's effects. | ||
| SEX | the sex of an individual can influence drug action.Women may react more strongly to certain drugs than men do. | ||
| GENETIC FACTORS | each person's individual makeup causes slight differences in basic processes like metabolism and excretion,which then affect drug action | ||
| PATHOLOGICAL CONDITIONS | diseases can strongly affect how patients respond to drugs.Disease mat impair the organs necessary for matabolism and excretion.Diseases of the liver and kidneys,especially,affect the processing and elimination of drugs. | ||
| PSYCHOLOGICAL FACTORS | the patients mental state is an important factor in the success or failure of drug thearpy; a patient with a positive attitude is likely to respond well to a medication. | ||
| ROUTE OF ADMINISTRATION | drugs are absorbed,distributed,and metabolized differently when given diffenet routes;route affects drug action,;drugs act most quickly when injected directly into the bloodstream;injected into or under the skin or into muscles require more time; | drugs adiminstered by mouth takes the longest time. | |
| TIME OF ADMINISTRATION | drugs taken orally are absorbed most quickly if the gs tract is free of free of food | ||
| DRUG-TAKING HISTORY | drug action depends on whether a patient has previously taken doses of the same or anothr drug | ||
| ENVIRONMENTAL CONDITIONS | heat relaxes the blood vessels and speeds up the circulation,so drugs act faster.cold slows their action by constricting the blood vessels and slowing the circulation. | ||
| THERAPEUTIC EFFECT | the desired effect,or the reason the drug is administered, | ||
| SIDE EFFECTS | additonal effects on the body that are not part of the goal of therapy;may be desirable or undesirable | ||
| ADVERSE REACTIONS | the body has an unexpected or dangerous response to a drug; | the most common are allergy,anaphylaxis,idiosyncrasies,tolerance,cumulative effect,overdose,toxicity and drug overdose. | |
| DRUG ALLERGY | an abnormal response that occurs because a person has developed antibodies against a particuar drug. | ||
| ANAPHYLAXIS | an extreme hypersensitivity reaction to a previously encountered antigen;can be life threatening;may be local or systemic | ||
| IDIOSYNCRASIES | are thought to be caused by an abnormal metabolism of drugs as the result of an enzyme deficiency.;people have abnormal or peculiar responses to certain drugs. | ||
| TOLERANCE | is the need for increasingly larger doses of a drug to produce the same physiological and/or psychological effects | ||
| OVERDOSE | a dose that is too large for his or her age,size,and/or physcial condition. | ||
| TOXICITY | refers to the drug's ability to poision the body. | ||
| DRUG ABUSE | refers to self-administration of a drug in a chronically excessive quanities,resulting in a psychological or physical dependence. | ||
| DRUG MISUSE | the overuse or careless use of any drug,including alcohol. | tranquilizers,stimulants,pain killers are frequently misused | |
| ABSORBITON | the passage of a drug from the site of administration into the blood stream.;usually there is a large range of blood levels to be therapeutic.;the rate of absorbtion is influenced by the route of administration. | The rate of absorbtion is influenced by the route of administration,the ability of the drug to dissolve,and the conditions at the site of absorbtion.The various routes of absorbtion is sublingual,oral,subcutaneous,intramuscular,intravenous,and topical. | |
| METABOLISM/BIOTRANSFORMATION | a series of chemical reactions that inactivate a drug by converting it into water-soluble compound so that it can be excreted by the body.Most of the metabolism and detoxification of drugs takes place in the liver. | the process of metabolism occurs under the influence of enzymes,which are proteins.These enzymes not only break down the drug,but also detoxify,or elimate subtances that are toxic to the body. | To some extent metabolism and detoxification takes place in the lungs,intestines,kidneys and blood.If a person is an older adult,pediatric,or has a decrease in liver function,there my be an insufficient metabolism of the drug,and the risk of drug toxicity |