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Skel.Muscle Relaxant

Pharmacology, Medicinal

QuestionsAnswer
What are the 3 types of skeletal muscle relaxants? Neuromuscular Blockers Central Acting Direct Acting
Dantrolene is what type of skeletal muscle relaxant? Direct Acting
What are the two subtypes of neuromuscular blockers? Competitive (non-depolarizing) and Depolarizing
Which type of relaxant can cause flaccid paralysis? Neuromuscular blocker
Diazepam and Bacclofen are what type of relaxants? Specific central acting
What drug is a central acting non-specific muscle relaxant? Tizanidine (Zanaflex)
True or False Succinylchloride is a depolarizing neuromuscular blocker? True
Which type of skeletal muscle relaxant class can be reversed using an Ache Inhibitor such as Neostigmine or Edrophonium and Atropine? Neuromuscular blocker
Produces short and persistent fasciculations? Succinylchloride
Can not reversed by Acetylcholinesterase Inhibitors b/c its non-competitive Succinylchloride
S/e include: respiratory paralysis, artificial respiratory ,autonomic ganglia CV: tachycardia (blockade of parasympathetic ganglia) or bradycardia (stimulation of parasympathetic ganglia) Neuromuscular blockers
Large amounts of histamines can cause blood pressure to increase or decrease? Blood pressure decreases
True or False, succinylchloride can be given in conjunction with a competitive agent as long as the patient is titrated? True
Centrally acting specific muscle relaxants work by which receptor? GABA
Tizanidine inhibits the release of what excitatory receptor? Glutamate (amino acid NT)
Side effects of Tizanidine include: hypotension and dizziness
Dantrolene binds to which receptor? RyR1 (ryanodine receptor)
RyR2 is found where? The heart
Dantrolene mechanism of action? Blocks RyR1 receptor which inhibits the release of Ca+ in sarcoplasmic recticulum, which interferes with muscle contraction.
This drug can also be used I.V. to treat malignant hyperthermia? Dantrolene
Malignant hyperthemia symptoms include: tachycardia, high temperatures (108), muscle rigidity, cyanosis
What are some non-specific central acting dugs? Carisporodol (Soma~IV) Methocarbonol (Robaxin) Metaxalone (Skalexin) Cyclobenzaprine (Flexeril) (dry mouth, blurred vision) Chlozazone (Paraflex)
Centrally acting drugs are administered how? P.O
Centrally acting drugs work by what mechanism of action? decrease synaptic transmission of impulses in spinal cord
Drugs ending in curonium or curium are of what skeletal muscle relaxant class? Competitive neuromuscular blockers
Created by: dbpharm13
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