click below
click below
Normal Size Small Size show me how
Pharm lecture 1
| Question | Answer |
|---|---|
| Highly protein bound drugs | Warfarin, Phenytoin, Propranolol, Diazapam |
| Henderson-Hasselbach Equation | PH= pKa+log Proton Acceptor/Proton Donor |
| Zero Order | A constant amount of drug cleared per unit of time, always a specific amount |
| First Order | Almost all drugs are cleared from circulation @ a rate proportional to the amount present in plasma |
| Bioavailability | The degree to which a drug or other substance becomes available to the target tissue after administration |
| Clearance | The rate a substance is removed from the blood by the body. (kidneys, liver, lungs, hemodialysis, ect) |
| What drug/patients characteristics will effect bioavailability? | 1. Lipid Solubility 2. Ionization a. Ionization med trick b. acids donate protons c. bases accept protons d. weak acids will be more non-ionized in acid solution e. weak bases are more ionized in a basic solution |
| What pt/drug characteristics effect Vd? | Pts: Kidney function, liver function, metabolism, age Drugs: Vd= Dose/Cpp Lipid solubility, protein binding, molecular size |