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cardioA&P 6,7,8 KAT
rspt 1207 Unit IV NOrma
Question | Answer |
---|---|
What are the two two froms that O2 is carried in? | 1)dissolved O2 in the blood plasma? 2)chemically bound to Hb |
What are the normal values for a arterial blood gas? | ph- 7.35-7.45, PCO2-35-40mmHg(PaCO2), HCO3 - 22-28 mEg/L, PO2 - 80-100 mmHg (PaO2) |
What are the normal values in a venous blood gas? | pH - 7.30-7.40, PCO2 - 42-48 mmHG (PVCO2), HCO3 - 24-30mEq/L, PO2 - 35-45mmHg (PVO2) |
At normal BTPS, How many mL of O2 will dissolve in 100mL of blood for every 1 mmHG of PO2? What law is this? | 0.003, Henry's Law |
What does Hb A consist of: | 1)4 heme groups 2)4 amino acid chains (polypeptide chains) |
What is a globin? | a protein |
how many oxygen molecules can a combine with Hb? | 4, one per heme/iron group |
What is the term used for Hb + O2? | oxyhemoglogin |
what is the term used for Hb not bound with O2? | reduced Hb / deoxyhemoglobin |
What two identical chians does the Hb molecule consist of? | 2 alpha (141 amino acids),2 Beta ( 146 amino acids) |
What does the normal Fetal Hb consist of? | 2 alpha chains, 2 gamma chians |
What is fetal Hb replaced with gradually? How long does it take? | Hb A, happens over the first year of postnantal life |
normal Hb is capable of carrying how many vol% | 0.3vol% |
What is Hb S? What is effected in this Hb? | sickle cell Hb, it has a different AA substitued in the beta chain:cause the deoxygenated Hb to change the shape of the RBC to sickle shape. |
What is the term used for Hb + O2? | oxyhemoglogin |
what is the term used for Hb not bound with O2? | reduced Hb / deoxyhemoglobin |
What two identical chians does the Hb molecule consist of? | 2 alpha (141 amino acids),2 Beta ( 146 amino acids) |
What does the normal Fetal Hb consist of? | 2 alpha chains, 2 gamma chians |
What is fetal Hb replaced with gradually? How long does it take? | Hb A, happens over the first year of postnantal life |
normal Hb is capable of carrying how many vol% | 0.3vol% |
What is Hb S? What is effected in this Hb? | sickle cell Hb, it has a different AA substitued in the beta chain:cause the deoxygenated Hb to change the shape of the RBC to sickle shape. |
What is the term used for Hb + O2? | oxyhemoglogin |
what is the term used for Hb not bound with O2? | reduced Hb / deoxyhemoglobin |
What two identical chians does the Hb molecule consist of? | 2 alpha (141 amino acids),2 Beta ( 146 amino acids) |
What does the normal Fetal Hb consist of? | 2 alpha chains, 2 gamma chians |
What is fetal Hb replaced with gradually? How long does it take? | Hb A, happens over the first year of postnantal life |
normal Hb is capable of carrying how many vol% | 0.3vol% |
What is Hb S? What is effected in this Hb? | sickle cell Hb, it has a different AA substitued in the beta chain:cause the deoxygenated Hb to change the shape of the RBC to sickle shape. |
Waht is the normal Hb Value of an ADULT MALE? | 14-16g/100ml |
What is the normal Hb value an ADULT FEMALE? | 12-15g/100ml |
What is the normal Hb value for an infant? | 14-20g/100ml |
What % of an RBC's wirght is Hb? | 33% |
What are your 3 physiological shunts? | Thebesian venous drainage into left atrium, Brobchiole venous drainage into pulmonary veins & Alveolar that are under ventilated relative to pulmonary blood. |
CaO2 (O2 Content of arterial blood) Formula | = (Hb * 1.34 * SaO2)+(PaO2 * 0.003) |
CvO2 (O2 Concentration of mixed venous blood) Formula | = (Hb * 1.34 * SvO2)+(PvO2 * 0.003) |
CcO2 (O2 Content of pulmonary capillary blood) Formula | = (Hb * 1.34)+(PAO2 * 0.003) |
What causes the O2 dissociation curve to shift to the left? | Increased pH, Decreased PcO2, Decreased Temp, Decreased 2,3-DPG |
What causes the O2 dissociation curve to shift to the right? | Decreases pH, Increased PcO2, Increased Temp, Increased 2,3-DPG |
What is P50? | A point of reference on the curve that represents the partial pressure at which Hb is 50% saturated with O2. |
Waht is the normal Hb Value of an ADULT MALE? | 14-16g/100ml |
What is the normal Hb value an ADULT FEMALE? | 12-15g/100ml |
What is the normal Hb value for an infant? | 14-20g/100ml |
What % of an RBC's wirght is Hb? | 33% |
What are your 3 physiological shunts? | Thebesian venous drainage into left atrium, Brobchiole venous drainage into pulmonary veins & Alveolar that are under ventilated relative to pulmonary blood. |
CaO2 (O2 Content of arterial blood) Formula | = (Hb * 1.34 * SaO2)+(PaO2 * 0.003) |
CvO2 (O2 Concentration of mixed venous blood) Formula | = (Hb * 1.34 * SvO2)+(PvO2 * 0.003) |
CcO2 (O2 Content of pulmonary capillary blood) Formula | = (Hb * 1.34)+(PAO2 * 0.003) |
What causes the O2 dissociation curve to shift to the left? | Increased pH, Decreased PcO2, Decreased Temp, Decreased 2,3-DPG |
What causes the O2 dissociation curve to shift to the right? | Decreases pH, Increased PcO2, Increased Temp, Increased 2,3-DPG |
What is P50? | A point of reference on the curve that represents the partial pressure at which Hb is 50% saturated with O2. |
What is the normal range for P50? | 27 mmHg |
What happens to P50 when the O2 dissociation curve shifts to the right? | Affinity of Hb for O2 decreases so Hb is less saturated at a given PO2 causing P50 to increase. |
What happens to P50 when the O2 dissociation curve shifts to the left? | Affinity of Hb for O2 increases so Hb is more saturated at any given PO2 causing P50 to decrease. |
What does Hypoxia do to the 2,3-DPG level regardless of the cause? | It causes it to increase |
Why do anemic patients not show signs and symptoms of Hypoxia? | Because the 2,3-DPG level increases as Hb concentration decreases |
What is 2,3-DPG? | A metabolic intermediary that is formed by RBCs during anaerobic glycolysis. |
What is the Bohr Effect? | Effect of PcO2 and pH on the oxyhemoglobin curve. |