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Schizophrenia
Drug Interactions,Food Interactions, Brand & Generic
| Question | Answer |
|---|---|
| Nigrostriatal tract blockade effects: | Movement Disorders |
| Mesolimbic tract blockade effect: | Relief of pyschosis |
| Mesocortical tract blockade effect: | Negative symptoms |
| Tuberfundibular tract blockade effect: | Increased prolactin release |
| Positive Symptoms include: | Delusions, hallucinations, disorganized speech, unusual behavior, psychomotor agitation |
| Negative Symptoms include: | Blunted effect, alogia, avolition, anhedonia, psychomotor retardation, poor self care |
| Dopamine D2 | S/e-EPS, tardive dyskinesia, galactorrhea, gynecomastia, sexual dysfunction |
| 5-HT2A | reduce EPS,can cause sexual disturbances, ortho hypotension |
| 5-HTC2 | Weight gain |
| Histamine H-1 | s/e-sedation, increased appetite, weight gain, hypotension |
| Typical Antipsychotics block which receptors? | D-2 |
| Atypical treats positive or negative symptoms? | It treats both |
| 5-HT3 blockade | causes antiemetic effect |
| Metabolic syndrome associated with which drug classes? | Antipsychotics |
| Typical antipsychotics that are available in soution, tablet, injection, and IM depot? | Fluphenazine (Prolixin) Haloperidol (Haldol) |
| 5-HT1 | Blockade causes increased anxiety and depression |
| requires monitoring, high doses cause paradoxyl effect-drooling, seizures. Tx initial-q week 6 months q-2 weeks for another 6 months q-4 weeks total time of medication -Pregnancy category B and can cause agranulocytosis | Clozapine (Clozaril) |
| Depot long acting injection, wait until 3 hrs after usage because it causes excessive sedation? | Olanzapine (Rel-Prev) |
| This drug works as an antagonist and happens by a decrease of dopamine in the mesolimbic system and an increase in dopamine in the mesocortical system | Abilify (Ariprazole) |
| Only atypical antipsychotic that is available as an sublingual tablet | Asenapine (Saphris) |
| Atypical drugs available as depot injections: | Risperidone (Risperdal), Olanzapine(Rel-Prev), Paliperidone(Sustenna) |
| Class of antipsychotics that has a higher incidence of EPS and lower incidence of anticholinergic effects, EPS, and is effective with both positive and negative symptoms? | Atypical antipsychotics |
| Only treats positive symptoms, lower incidence of metabolic syndrome & higher incidence of EPS and anticholinergic effects | Typical antipsychotics |
Created by:
dbpharm13
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