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Intro

neurons and glial cells

QuestionAnswer
stereoisomers two forms of same drug, mirror images
Dose responsive curves dose and effect graph
Effective Dose % of people for whom dose will be effective
lethal dose % of fatalities at drug dose
safety margin difference between ED and LD
potency strength of binding of drug
stereoisomers two forms of same drug, mirror images
Dose responsive curves dose and effect graph
Effective Dose % of people for whom dose will be effective
lethal dose % of fatalities at drug dose
safety margin difference between ED and LD
potency strength of binding of drug
bio-availibility how well drug gets to site of action
Two categories drug effects agonist and antagonist
agonist drug binds to receptor mimics neurotransmitter
antagonist binds to receptor no biologicaleffect
inverse agonist binds opposite effect of agonist
high thru put testing simulations of dose response curves
3 traits of receptor binding saturability, selectivity, reversibility
saturability all receptors occupied
selectivity receptors selective binding not strong
reversibility binding is usually reversible
high affinity stay long time on receptor
low affinity stay on receptor for short time
biological membrane made of lipid molecules 1/2 hydrophobic 1/2 hydrophylic
bilipid membrane spontaneously formed
neuron tail where protein binding occurs
2 elements maintain shape of neuron Membrane associate protiens (MAP) microtubules
microfilliments transport vesicles up and down axon break during dementia
exocytosis NT released into synaptic gap
axo-dendric synapse linear
denrodenritic synapse two way communication not linear
glial cells other half of brain cells that are not neurons
4 classes of glial cells astroglia, microglia, oligiodendricyte, Schwann
Blood brain barrier to pass molecule must be small, highly lipid soluable, electronegativity
astroglia gives nutrients from blood to axon on neuron
microglia tiny migrating cells
phagocytes microglia that eat dead cells in brain
oliogiodendrycite PNS produce mylein
schwan CNS each cell only one node in mylein sheath
electronegativity how electric chemical s are able to give and take electrons
less polarized more lipid soluable get to brain faster
Created by: 100001074223617
Popular Pharmacology sets

 

 



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