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Yecko Antibio. Ionof

Antibióticos Ionóforos

QuestionAnswer
Familia de farmacos que actúan protegiendo la carga del ion neto Antibioticos ionóforos
Tipos de antibioticos ionóforos. Acarreadores móviles y formadores de canales
Es un acarreador mobil, peptido ciclico lactona. Valinomicina
Es un formador de canales péptido lineal: Gramicidina A
Son pequeñas moleculas hidrofobicas que se disuelven en las bicapas lipídicas e incrementan su permeabilidad. Ionóforos
Tipo de antibiotico ionóforo que atrapa al ion y la manda al otro lado de la membrana. Acarreadores móviles
Tipo de antibiotico ionóforo que crea un tunel polar que permite la migracion de iones polares. Formadores de canales
¿Qué debe de perder el K para que pueda ser acarreado por la valinomicina? Esfera de hidratacion
¿Cuál es la selectividad de la valinomicina por el K sobre el Na? 1,000:1
¿Por que la valinomicina acarrea al K y no al Na? Por que es mas largo
La valinomicina forma dímeros para deterner firmemente al K ¿V o F? Verdadero
¿Cómo de forma los canales la gramicidina A? Formando dímeros, uniendo colas a traves de la membrana
Los canales que forma la gramicidina son selectivos para el transporte de iones: monovalentes
¿Como deben de estar los iones para ser transportados? Anhidro
¿Cuantos iones transporta la gramicidina? 1,000,000:1
Los dímeros no se disocian constantemente y son estables ¿V o F? Falso
¿Por que los antibióticos ionoforos no tienen uso clínico? Porque no tienen selectividad entre las celulas
Created by: yEck0o WhArh0ol
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