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EAP Mod 6 Vocabulary
Experimental Analysis of Behavior Module 6 Vocabulary and Definitions
| Term | Definition |
|---|---|
| Pharmacokinetics | the way in which drugs are absorbed, transformed/distributed as they metabolize, and excreted within the body, within behavioral context it helps to understand how drugs move through the body |
| Pharmacodynamics | the way in which the body interacts with the drug including receptor interaction and dose-response relationships, within behavioral context how the drug produces its mental/physiological effects and how it moves through the body |
| Absorption | the uptake and physiological process by which a drug moves from the route of administration and enters the circulatory system/bloodstream, also influenced by drug solubility and formulation, and contraindications |
| Distribution | post-absorption into the bloodstream, the physiological process by which a drug moves through the body to the site of action, influenced by blood flow, drug solubility, plasma protein binding, and blood-brain barrier permeability |
| Metabolism | the biochemical way in which the body and more specifically the liver transforms and breaks down a drug after absorption to prepare for elimination, modification/conjugation |
| Elimination | the way in which the body rids itself of drugs from the body including but not limited to kidney excretion, emesis, feces, and/or sweat, the half-life of chemical substance vital to consider |
| Dose-response curve | the relationship between dosage and its effects that helps determine efficacy and safety margins in behavioral pharmacology |
| Stimulants | drugs that increase central nervous system activity by increasing dopamine and norepinephrine activity causing increased alertness and reinforcement *schedules of reinforcement |
| Depressants | drugs that decrease CNS activity by enhancing GABAergic inhibition causing sedation, anxiolysis and impaired coordination *dose-dependent suppression of response rates |
| Opioids | drugs that act on mu-opioid receptors causing pain relief, euphoria, and respiratory depression *consider epidemic from behavioral perspective, strong reinforcement/tolerance/dependence |
| Cannabinoids | drugs that act on endocannabinoid system, specifically CB1 and CB2 receptors, effecting mood and causing relaxation, altered memory and appetite stimulation |
| Self-administration | subject's independent administration of a drug, in research the subject (animal) presses a ever to receive drug through designed mechanism |
| Reinforcer Efficacy | measures strength of a reinforcer, the strength is influenced by dose, delay, reinforcement schedule, individual health |
| Conditioned Place Preference | experimental methodology in the context of behavioral pharmacology wherein drug reinforcement is measured without requiring self-administration of drug by subject |
| Progressive Ratio Schedule | experimental methodology in the context of behavioral pharmacology wherein breakpoints are assessed for drug-seeking behavior |
| Breakpoint | during PR schedule it is the point (highest completed ratio) at which the subject stops responding to meet the requirement within a session or time limit, indicates reinforcing efficacy or motivational strength of a drug |
| Demand Curve (in dsa) | measure how a drug changes behavior in response to price increases |
| Drug Discrimination procedure | primarily conducted in animal subjects it is an operant conditioning procedure used to assess internal stimulus effects of drugs, subjects trained to respond differentially based on administration of either a drug A or B or placebo |
| Substitution (in dsa) | test used to determine whether two drugs produce similar reinforcing effects. |
| Generalization (in dsa) | assessment of whether subject is properly trained, extent to which novel drug produces similar effects to a known drug, and how quickly the task is learned as well as drug toxicity |
Created by:
Charleestar21
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