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NeuropLecture2 for 2

Neuropharm Lecture 2 for test 2

QuestionAnswer
Apoptosis Cell death in the brain
What are the Purines Purines are really small Molecules (they are actually chunks of DNA)
How is Adenosine released through a bidirectional transporter molecule
What is one of the products of ATP? One of the products of ATP is adenosine
Is Adenosine stored? Adenosine is not stored anywhere it is a bidirectional transporter molecule
Which of the Purines affects arousal? We know that Adenosine has something to do with arousal
What drug gets through the BBB with an N1 Purine Transporter The drug AZT (zidovudine) gets through the BBB with an N1 Purine Transporter
What are the Purine Transporters There are four types N1-N4
What are the Methylxanthines? caffeine, theophylline (tea)and theobromine (chocolate)These three methylxanthines are all related to arousal and vigilance
What are some Adenosine Antagonists (P1 Antagonists)? caffeine, theophylline (tea)and theobromine (chocolate)
What effect do P1 Agonists have? P1 Agonists decrease anxiety but produce analgesia
What receptors do caffeine bind on? caffeine binds on adenosine receptors
What do the Adenosine Agonists do? the adenosine agonists inhibit glutamate release Pa1 receptors
How is glutamate stopped from being released? The agonist adenosine comes and binds to the cell and stops glutamate from being released
How much caffeine in a cup of coffee? 100 mg of caffeine in a cup of java
How much caffeine in a 12 oz cola? 45% caffeine in a 12 oz cola The govt established that there can not be more than 72 grams per 12 oz
How much caffeine in chocolate? 20 mg per ounce
How much caffeine in No Doze? 100 mg per tablet
How much caffeine in Excedrin or Aspirin? about 65 mg but first you get the vasodilator and then you get the caffeine
How much caffeine in Dexatrim? About 200 mg of caffeine per tablet
What is TRK? The Tyrosine Kinase receptors are called TRK
What are neurotrophins? All neurotrophins are small peptides
What is BDNF? BDNF is brain derived neurotrophic factors.
What is GDNF? GDNF is Nerve Growth neurotrophic factors.
What are cytokines? Cytokines are A class of neurotrophic factors
How do we suspect that Cytokines enter the brain? Cytokines probably enter the brain where the BBB is not well established so that signifies that the entry would be down by the hypothalam because that’s where the leaky BBB’s are
What happens when the chemokines get developed? They head for your brain to kill brain cells and cause neuron death
what the hell does mike havens want from us? confusion
Created by: julie livingston
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