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NeuropLecture2 for 2
Neuropharm Lecture 2 for test 2
| Question | Answer |
|---|---|
| Apoptosis | Cell death in the brain |
| What are the Purines | Purines are really small Molecules (they are actually chunks of DNA) |
| How is Adenosine released | through a bidirectional transporter molecule |
| What is one of the products of ATP? | One of the products of ATP is adenosine |
| Is Adenosine stored? | Adenosine is not stored anywhere it is a bidirectional transporter molecule |
| Which of the Purines affects arousal? | We know that Adenosine has something to do with arousal |
| What drug gets through the BBB with an N1 Purine Transporter | The drug AZT (zidovudine) gets through the BBB with an N1 Purine Transporter |
| What are the Purine Transporters | There are four types N1-N4 |
| What are the Methylxanthines? | caffeine, theophylline (tea)and theobromine (chocolate)These three methylxanthines are all related to arousal and vigilance |
| What are some Adenosine Antagonists (P1 Antagonists)? | caffeine, theophylline (tea)and theobromine (chocolate) |
| What effect do P1 Agonists have? | P1 Agonists decrease anxiety but produce analgesia |
| What receptors do caffeine bind on? | caffeine binds on adenosine receptors |
| What do the Adenosine Agonists do? | the adenosine agonists inhibit glutamate release Pa1 receptors |
| How is glutamate stopped from being released? | The agonist adenosine comes and binds to the cell and stops glutamate from being released |
| How much caffeine in a cup of coffee? | 100 mg of caffeine in a cup of java |
| How much caffeine in a 12 oz cola? | 45% caffeine in a 12 oz cola The govt established that there can not be more than 72 grams per 12 oz |
| How much caffeine in chocolate? | 20 mg per ounce |
| How much caffeine in No Doze? | 100 mg per tablet |
| How much caffeine in Excedrin or Aspirin? | about 65 mg but first you get the vasodilator and then you get the caffeine |
| How much caffeine in Dexatrim? | About 200 mg of caffeine per tablet |
| What is TRK? | The Tyrosine Kinase receptors are called TRK |
| What are neurotrophins? | All neurotrophins are small peptides |
| What is BDNF? | BDNF is brain derived neurotrophic factors. |
| What is GDNF? | GDNF is Nerve Growth neurotrophic factors. |
| What are cytokines? | Cytokines are A class of neurotrophic factors |
| How do we suspect that Cytokines enter the brain? | Cytokines probably enter the brain where the BBB is not well established so that signifies that the entry would be down by the hypothalam because that’s where the leaky BBB’s are |
| What happens when the chemokines get developed? | They head for your brain to kill brain cells and cause neuron death |
| what the hell does mike havens want from us? | confusion |