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Neuropharm2
Neuropharmacology
| Question | Answer |
|---|---|
| What is Nociception | a neurophysiological term that refers to our ability to detect noxious stimuli. |
| Where are the Morphine receptors? | mu receptors are in areas like the dorsal horn on c fiber terminals which are activated by descending pain information. |
| What drug is an agonist that has been used with feeding problems and also to treat obesity | Y-5 is an antagonist for treating obesity and an agonist for treating anorexia |
| What are Substance P Pronociceptive? | These are antagonists that don’t stop pain |
| What is Y-1 | One of the six receptors for neuropeptide y It is an agonist, when stimulated it decreases anxiety. |
| How are neuropeptides released? | Kind of like neurotransmitters but they are released in the nucleus or right next to the nucleus. |
| Where are the neuropeptides packaged | In vesicles called Large Core Vesicles |
| What happens to the PreProtachykinin upon its release? | It gets cleaned and turned into a bunch of pieces. Each piece has 2 sets of P's, 1 neuropeptide Y and several other peptides. All of the receptors are meabotrophic G protein coupled. |
| What are the three opioid receptors | Mu Kappa, Delta |
| Where are the opioid receptors in the brain? | The Dorsal Horn on c fiber terminals, The Spinal Cord aka Substantia Gelatinosa |
| What is morpheine? | The purified poppy sap of the opium poppy |
| How are the neuropeptides different from the neurotransmitters? | Peptides are unusually long things with several neuropeptides in them. |
| What are the three receptors for Substance P? | NK 1-3 These are basically in the basal horn and amygdyla |
| where do you typically find Neuropeptide Y | in the cortex, the Dorsal Horn and the Hypothalamus |
| What are the 6 receptors for Neuropeptide Y? | Y1-Y-6 |
| What did we use previously to cause anxiety? | Caffeine huge amounts of it given over the period of several days and then when withdrawal occurs anxiety is seen. |
| When conducting the mouse in the maze study, how did we know when the mouse was no longer feeling anxiety | when the mouse went to the open arm. |
| What does the binding of an opiate to c fibers cause? | Presynaptic Inhibition |
| What are two low potency mu agonists that can be combined with acetominophen (Percocet) | Codeine and oxycodone (Percolone) |
| What are two high potency mu agonists that produce activation of the receptor with large decreases in pain but also tolerance and side effects? | Hydromorphone HCL (Dilaudid) and Fentanyl (Sublimaze) |
| What might an opiate antagonist be commonly used to treat? | Heroin addiction or Alcoholism |
| What might an opiate antagonist be commonly used to treat? | Heroin addiction or Alcoholism |
| What are the (NSAIDS) | The Nonsteroidal antiinflammatory drugs like ibuprophen, aspirin, indomethacin (Indocin) |
| How do the NSAIDS work? | These drugs block prostaglandin synthesis by blocking the enzyme cyclooxygenase. |
| What are two of the non opioid Non NSAIDS analgesics? | Nicotine and marijuana |
Created by:
julie livingston
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