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Pain,Hem, Oncology 3

GenericBrandCategoryIndicationEK
methotrexate (PO, IV, IT) Trexall Antimetabolite (folic acid antagonist) Rheumatoid arthritis, Crohn’s Disease, psoriasis, various hematologic and solid tumors SE: stomatitis, diarrhea, N/V, thrombocytopenia, leukopenia, ↑ LFTs, rare pulm fibrosis. BBW: severe toxicity; fetal death/teratogenic; severe BM suppression; hepatotoxic; pneumonitis; ↑ toxicity w/ NSAIDs. Notes: give folic acid ↓ heme/GI/hepatic SE.
cisplatin (IV, IT, IP) Kemoplat Antineoplastic agent, platinum- based compound Advanced bladder, ovarian, and testicular cancer; various cancers Key Side Effects: bone marrow suppression, nausea, vomiting, nephrotoxicity, neurotoxicity, ototoxicity US Boxed Warnings: may cause severe myelosuppression, nausea and vomiting, renal toxicity, and dose-related neuropathy
doxorubicin (IV) Adriamycin Antineoplastic agent, anthracycline Adjuvant therapy for breast cancer, various cancers SE: cardiomyopathy, alopecia, N/V, BM suppression. BBW: cardiomyopathy, myelosuppression, secondary malignancies; extravasation → severe tissue injury/necrosis. Notes: red discoloration of urine, tears, sweat, saliva.
pembrolizumab (IV) Keytruda Antineoplastic agent, monoclonal antibody Various cancers Key Side Effects: peripheral edema, pruritus, skin rash, endocrine and metabolic abnormalities, constipation, diarrhea, nausea, vomiting, hematuria, anemia, increased liver enzymes, fatigue, musculoskeletal pain, increased serum creatinine, dyspnea
anastrozole (PO) Arimidex Aromatase inhibitor Hormone receptor-positive breast cancer Key Side Effects: fatigue, rash, flushing, hot flashes, arthralgia, nausea, vomiting, hypertension, peripheral edema, osteoporosis Other Notes: cardiovascular side effects (i.e., hypercholesterolemia, CAD); fetal toxicity (CI in pregnancy)
tamoxifen (PO) Soltamox Selective estrogen receptor modulator (SERM) Hormone receptor-positive breast cancer SE: hot flashes/night sweats, vaginal bleeding/discharge, ↓ BMD (premenopausal). BBW: ↑ uterine/endometrial cancer; thromboembolic events. Notes: use contraception (teratogenic); avoid w/ warfarin or hx DVT/PE.
Created by: PharmacistJulian
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