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Musculoskeletal
| Generic | Brand | Category | Indication | EK |
|---|---|---|---|---|
| tizanidine (PO) | Zanaflex | Alpha 2 agonist | Spasticity | Key Side Effects: drowsiness, hypotension, dizziness, xerostomia, weakness |
| hydroxychloroquine (PO) | Plaquenil | Aminoquinolone | RA, SLE, malaria | Key Side Effects: retinal toxicity, rash, diarrhea Other Notes: long-term use has been associated with cardiomyopathy, bone marrow suppression, QT prolongation, and neuromuscular effects (i.e., myopathy, palsies, and progressive weakness) |
| diclofenac (topical) | Voltaren Gel | NSAID | OA | Key Side Effects: pruritus, rash |
| diclofenac (PO) | Voltaren | NSAID | OA, RA, acute pain | SE: diarrhea, dyspepsia, abd pain, flatulence, nausea. BBW: ↑ CV thrombotic events (MI, stroke); ↑ GI ulcer/bleed/perforation. Notes: ↓ renal blood flow → worsens renal fxn; avoid in renal dz, HF, cirrhosis. |
| ibuprofen (PO) | Motrin, Advil | NSAID | OA, RA, acute pain | SE: diarrhea, dyspepsia, abd pain, flatulence, nausea. BBW: ↑ CV thrombotic events (MI, stroke); ↑ GI ulcer/bleed/perforation. Notes: ↓ renal blood flow → worsens renal fxn; avoid in renal dz, HF, cirrhosis. |
| meloxicam (PO) | Mobic | NSAID | OA, RA, acute pain | SE: diarrhea, dyspepsia, abd pain, flatulence, nausea. BBW: ↑ CV thrombotic events (MI, stroke); ↑ GI ulcer/bleed/perforation. Notes: ↓ renal blood flow → worsens renal fxn; avoid in renal dz, HF, cirrhosis. |
| indomethacin (PO) | Indocin | NSAID | OA, RA, acute pain, gout | SE: diarrhea, dyspepsia, abd pain, flatulence, nausea. BBW: ↑ CV thrombotic events (MI, stroke); ↑ GI ulcer/bleed/perforation. Notes: ↓ renal blood flow → worsens renal fxn; avoid in renal dz, HF, cirrhosis. |
| naproxen (PO) | Naprosyn, Anaprox, Aleve | NSAID | OA, RA, acute pain, gout | SE: diarrhea, dyspepsia, abd pain, flatulence, nausea. BBW: ↑ CV thrombotic events (MI, stroke); ↑ GI ulcer/bleed/perforation. Notes: ↓ renal blood flow → worsens renal fxn; avoid in renal dz, HF, cirrhosis. |
| ketorolac (PO, IV) | Toradol | NSAID | Pain | SE: diarrhea, dyspepsia, abd pain, flatulence, nausea. BBW: ↑ CV thrombotic events (MI, stroke); ↑ GI ulcer/bleed/perforation. Notes: ↓ renal blood flow → worsens renal fxn; avoid in renal dz, HF, cirrhosis. UBW no more than days |
| celecoxib (PO) | Celebrex | NSAID, COX-2 selective | OA, RA, acute pain | SE: diarrhea, dyspepsia, abd pain, flatulence, nausea. BBW: ↑ CV thrombotic events (MI, stroke); ↑ GI ulcer/bleed/perforation. Notes: ↓ renal blood flow → worsens renal fxn; avoid in renal dz, HF, cirrhosis. |
| cyclobenzaprine (PO) | Flexeril, Amrix, Fexmid | Skeletal muscle relaxant | Muscle spasm | Key Side Effects: drowsiness, dizziness, xerostomia, fatigue Other Notes: use may cause prolonged cardiac arrhythmias, and tachycardia; CI within 14 days of MAOI therapy |
| baclofen (PO) | Skeletal muscle relaxant | Spasticity | Key Side Effects: drowsiness | |
| methocarbamol (PO) | Robaxin | Skeletal muscle relaxant | Muscle spasm | Key Side Effects: drowsiness |
| lidocaine (transdermal, IV) | Transdermal: Lidoderm, IV: Xylocaine | Transdermal: topical analgesic IV: antiarrhythmic | Transdermal: pain, IV: ventricular arrhythmias | Key Side Effects (transdermal): dermatitis, erythema, urticaria, skin depigmentation, skin edema Key Side Effects (IV): bradycardia Other Notes: patch may remain in place for up to 12 hours in any 24-hour period, patch may be cut |
| colchicine (PO) | Colcrys | Antigout agent | Gout | Key Side Effects: diarrhea, nausea, vomiting, bone marrow suppression, myopathy (including rhabdomyolysis) |
| allopurinol (PO) | Zyloprim | Xanthine oxidase Inhibitor | Gout | Key Side Effects: diarrhea, nausea, rash, leukopenia, thrombocytopenia Other Notes: rare association with severe (and potentially fatal) allopurinol hypersensitivity syndrome (risk highest in certain Asian populations) |
| succinylcholine (IV) | Anectine | Depolarizing neuromuscular blocking agent | Neuromuscular blockade for intubation or procedures | Key Side Effects: hyperkalemia, myalgia, malignant hyperthermia (rare) US Boxed Warning: acute rhabdomyolysis and hyperkalemia leading to cardiac arrest and death in pediatric patients with undiagnosed skeletal muscle disease |
| etanercept (SQ) | Enbrel | Anti-tumor necrosis factor alpha inhibitor | RA | Key Side Effects: infection, injection site reaction, headache, nausea US Boxed Warning: serious infections, malignancies such as lymphoma |
| adalimumab (SQ) | Humira | Anti-tumor necrosis factor alpha inhibitor | RA, Crohn’s Disease, Ulcerative Colitis | Key Side Effects: infection, injection site reaction, headache, nausea US Boxed Warning: serious infections, malignancies such as lymphoma |
Created by:
PharmacistJulian
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