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CNS 3

GenericBrandCategoryIndicationEK
lithium (PO) Lithobid Antimanic agent Bipolar disorder SE: tremor, acne, hypothyroid, wt gain, polyuria/polydipsia, GI upset. BBW: requires prompt level monitoring. Notes: narrow TI (toxicity near therapeutic levels → TDM needed); avoid in pregnancy
sumatriptan (PO, intranasal, SQ) Imitrex Antimigraine Migraine Key Side Effects: fatigue, somnolence, dizziness, chest tightness, paresthesias Other Notes: CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension
rizatriptan (PO) Maxalt Antimigraine Migraine Key Side Effects: fatigue, somnolence, dizziness, chest tightness, paresthesias Other Notes: CI in ischemic heart disease, history of stroke or TIA, peripheral vascular disease, and uncontrolled hypertension
haloperidol (PO, IV, IM) Haldol First-generation antipsychotic Schizophrenia Key Side Effects: sedation, EPS, parkinsonism, xerostomia, orthostatic hypotension, weight gain, QTc prolongation US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death
clozapine (PO) Clozaril Second- generation antipsychotic Treatment- resistant schizophrenia SE: sedation, constipation, orthostasis, sialorrhea, hyperglycemia, wt gain, neutropenia. BBW: severe neutropenia; orthostasis/bradycardia/syncope; seizures; fatal myocarditis/cardiomyopathy; ↑ death risk in elderly w/ dementia psychosis.
aripiprazole (PO, IM) PO/IM: Abilify; IM: Aristada Second- generation antipsychotic Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) SE: akathisia/restlessness, sedation, EPS, constipation, orthostasis, wt gain. BBW: ↑ suicidal thoughts/behavior in children, adolescents, young adults; ↑ death risk in elderly w/ dementia psychosis on antipsychotics.
quetiapine (PO) Seroquel, Seroquel XR Second- generation antipsychotic Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) SE: sedation, EPS, constipation, orthostasis, wt gain. BBW: ↑ suicidal thoughts/behavior in children, adolescents, young adults; ↑ death risk in elderly w/ dementia psychosis on antipsychotics.
lurasidone (PO) Latuda Second- generation antipsychotic Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) SE: sedation, EPS, constipation, orthostasis, wt gain. BBW: ↑ suicidal thoughts/behavior (children, adolescents, young adults); ↑ death risk in elderly w/ dementia psychosis on antipsychotics. Notes: CI w/ strong CYP3A4 inhibitors/inducers.
olanzapine (PO, IM) Zyprexa Second- generation antipsychotic Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) Key Side Effects: sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death
risperidone (PO, IM) PO: Risperdal IM: Risperdal Consta Second- generation antipsychotic Schizophrenia Key Side Effects: sedation, EPS, xerostomia, constipation, orthostatic hypotension, weight gain, hyperglycemia US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death
Created by: PharmacistJulian
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