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ID 4
BDK
| Pharmacologic Category | Generic Name | Brand Name | Common Indication | Key Side Effects | BBW |
|---|---|---|---|---|---|
| Allylamine antifungal | terbinafine (PO, topical) | Lamsil | Onychomycosis | nausea, abdominal pain, diarrhea, elevated hepatic transaminases, headache | --- |
| Azole antifungal | fluconazole (PO,IV) | Diflucan | Vulvovaginal candidiasis, oropharyngeal candidiasis, invasive candidiasis | nausea, abdominal pain, diarrhea, QTc prolongation, increased hepatic transaminases | --- |
| Azole antifungal | ketoconazole (PO, topical) | Nizoral | Tinea infections | nausea, abdominal pain, diarrhea, QTc prolongation, increased hepatic transaminases | serious hepatotoxicity, including cases w/ a fatal outcome or requiring liver transplantation have occurred; may cause QTc prolongation and drug interactions leading to QTc prolongation |
| Polyene antifungal | nystatin (PO) | --- | Oropharyngeal candidiasis | phlebitis, diarrhea, vomiting, anemia, fever | --- |
| Polyene antifungal | nystatin (topical) | Nystop | Cutaneous and mucocutaneous fungal infections | burning, itching, Other notes: only use oral solutions for thrush | --- |
| Echinocandin antifungal | micafungin (IV) | Mycamine | Invasive candidiasis | no major side effects | --- |
| Glucocorticoid and azole antifungal | betamethasone and clotrimazole (topical) | Lotrisone | Cutaneous fungal infections | burning, itching, dryness, skin atrophy; Other Notes: do not use for diaper dermatitis; adrenal suppression w/ long-term use over large areas of skin | --- |
| Neuraminidase inhibitor antiviral | oseltamivir (PO) | Tamiflu | Influenza | nausea, vomiting, neuropsychiatric events (i..e. confusion, delirium, hallucinations) in pediatric patients (rare) | --- |
| Antiviral | acyclovir (PO,IV) | Zovirax | Herpes simplex virus | nausea, increased hepatic transaminases, crystalluria; ON: vesicant | --- |
| Antiviral | valacyclovir (PO) | Valtrex | Herpex simplex virus | nausea, increased hepatic transaminases | --- |
| Antiviral | nirmatrelvir + ritonavir (PO) | Paxlovid | COVID-19 | diarrhea, dysgeusia | significant drug interactions; strong CYP3A inhibitor |
| Antiviral | remdesivir (IV) | Veklury | COVID-19 | hyperglycemia, renal impairment | --- |
| Nucleoside/Nucleotide Reverse Transcriptase Inhibitor (NRTI) | emtricitabine + tenofovir disoproxil fumarate (PO) | Truvada | HIV infections, PreP, PEP | decreased bone mineral density, kidney injury, nausea, diarrhea | post treatment acute exacerbation of hepatitis B, risk of drug resistance w/ use of pre-exposure prophylaxis |
| Nucleoside/Nucleotide Reverse transcriptase Inhibitor (NRTI) + Integrase Strand transfer inhibitor (INSTI) | emtricitabine (NRTI) + tenofovir alafenamide + bictegravir (INSTI) (PO) | Biktarvy | HIV infection | increased serum bilirubin, headache, weight gain, insomnia, diarrhea, nausea, ON: take oral INSTIs 2 hr before or 6 hr after products containing Ca, Al,Mg,Fe | post treatment acute exacerbation of hepatitis B |