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ECM and cell junct.

cell biology

QuestionAnswer
what is the extracellular matrix? substances secreted from the cell that support it
function of the ECM cell support, adhesion, provides a substrate for movement, regulation of cell shape, cell survival and cell differentiation
fibrous substance network of protein fibers (mainly collagen) embedded in ground substance
ground substance an amorphous gel-like substance surrounding the cells; it is made of mainly proteoglycans and associated water molecules
what does the ground substance act as in the cell? lubricant and barrier
what are cellular junctions? connections between other cells and their extracellular matrix
tight junctions protein complexes that restrict paracellular movement (between the cells); the mainb protein components are claudins and occludins
gap junctions communicating junctions that connect cells to neighboring cells
how are gap junctions formed? from six connexin proteins that form a connexon with a central pore that directly connects the cytoplasm of adjacent cells
what do gap junctions allow to pass from cell to cell? water and small solutes
types of anchoring junctions desmosomes, adherens junctions, hemidesmosomes, and focal adhesions
desmosomes spot junctions made of cadherins that connects cells to other cells through interactions with intermediate filaments
adherens junctions junctions made of cadherins that connect cell-to-cell through microfilaments
hemidesmosomes junctions made of integrins that anchor cells to the extracellular matrix through interactions with intermediate filaments
focal adhesions junctions made of integrins that anchor cells to the extracellular matrix through interactions with microfilaments
Created by: angievelasco
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