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Pain, Hema, Onc 3
| Pharmacological category | Generic | Brand | Indication | Key side effects | US Boxed warning | Other notes |
|---|---|---|---|---|---|---|
| Antimetabolite (folic acid antagonist) | methotrexate (PO, IV, IT) | Trexall | Rheumatoid arthritis, Crohn’s Disease, psoriasis, various hematologic and solid tumors | stomatitis, diarrhea, nausea, vomiting, thrombocytopenia, leukopenia, increased hepatic transaminases, pulmonary fibrosis (rare) | look at BDK list | folic acid supplementation may be taken during use to reduce hematologic, gastrointestinal, and hepatic side effects |
| Antineoplastic agent, platinum- based compound | cisplatin (IV, IT, IP) | Kemoplat | Advanced bladder, ovarian, and testicular cancer; various cancers | bone marrow suppression, nausea, vomiting, nephrotoxicity, neurotoxicity, ototoxicity | may cause severe myelosuppression, nausea and vomiting, renal toxicity, and dose-related neuropathy | n/a |
| Antineoplastic agent, anthracycline | doxorubicin (IV) | Adriamycin | Adjuvant therapy for breast cancer, various cancers | cardiomyopathy, alopecia, nausea, vomiting, bone marrow suppression | may cause cardiomyopathy, myelosuppression, secondary malignancies; extravasation can result in severe local tissue injury and necrosis | may cause red discoloration of urine, tears, sweat, and saliva |
| Antineoplastic agent, monoclonal antibody | pembrolizumab (IV) | Keytruda | Various cancers | peripheral edema, pruritus, skin rash, endocrine and metabolic abnormalities, constipation, diarrhea, nausea, vomiting, hematuria, anemia, increased liver enzymes, fatigue, musculoskeletal pain, increased serum creatinine, dyspnea | n/a | n/a |
| Aromatase inhibitor | anastrozole (PO) | Arimidex | Hormone receptor-positive breast cancer | fatigue, rash, flushing, hot flashes, arthralgia, nausea, vomiting, hypertension, peripheral edema, osteoporosis | n/a | cardiovascular side effects (i.e., hypercholesterolemia, CAD); fetal toxicity (CI in pregnancy) |
| Selective estrogen receptor modulator (SERM) | tamoxifen (PO) | Soltamox | Hormone receptor-positive breast cancer | hot flashes/night sweats, vaginal bleeding/discharge, decreased bone density (in premenopausal females) | increased risk for uterine or endometrial cancer and thromboembolic events | contraception should be used in premenopausal females due to teratogenicity of the drug; do not use with warfarin or history DVT/PE |
Created by:
ziad5
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